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Page 1
FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing.
Wang Z, Dove P, Wang X, Shamas-Din A, Li Z, Nachman A, Oh YJ, Hurren R, Ruschak A, Climie S, Press B, Griffin C, Undzys E, Aman A, Al-awar R, Kay LE, O'Neill D, Trudel S, Slassi M, Schimmer AD. Wang Z, et al. Among authors: slassi m. Cell Death Dis. 2015 Jul 9;6(7):e1815. doi: 10.1038/cddis.2015.187. Cell Death Dis. 2015. PMID: 26158521 Free PMC article.
Novel proteasome inhibitors to overcome bortezomib resistance.
Ruschak AM, Slassi M, Kay LE, Schimmer AD. Ruschak AM, et al. Among authors: slassi m. J Natl Cancer Inst. 2011 Jul 6;103(13):1007-17. doi: 10.1093/jnci/djr160. Epub 2011 May 23. J Natl Cancer Inst. 2011. PMID: 21606441 Review.
Design, synthesis and biological activity of novel dimethyl-[2-[6-substituted-indol-1-yl]-ethyl]-amine as potent, selective, and orally-bioavailable 5-HT(1D) agonists.
Isaac M, Slassi M, Xin T, Arora J, O'Brien A, Edwards L, MacLean N, Wilson J, Demschyshyn L, Labrie P, Naismith A, Maddaford S, Papac D, Harrison S, Wang H, Draper S, Tehim A. Isaac M, et al. Among authors: slassi m. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4409-13. doi: 10.1016/j.bmcl.2003.09.025. Bioorg Med Chem Lett. 2003. PMID: 14643336