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Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, Bardeesy N. Perera RM, et al. Among authors: zoncu r. Nature. 2015 Aug 20;524(7565):361-5. doi: 10.1038/nature14587. Epub 2015 Jul 13. Nature. 2015. PMID: 26168401 Free PMC article.
The Lysosome as a Regulatory Hub.
Perera RM, Zoncu R. Perera RM, et al. Among authors: zoncu r. Annu Rev Cell Dev Biol. 2016 Oct 6;32:223-253. doi: 10.1146/annurev-cellbio-111315-125125. Epub 2016 Aug 3. Annu Rev Cell Dev Biol. 2016. PMID: 27501449 Free PMC article. Review.
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.
Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. Castellano BM, et al. Among authors: zoncu r. Science. 2017 Mar 24;355(6331):1306-1311. doi: 10.1126/science.aag1417. Science. 2017. PMID: 28336668 Free PMC article.
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.
Di Malta C, Siciliano D, Calcagni A, Monfregola J, Punzi S, Pastore N, Eastes AN, Davis O, De Cegli R, Zampelli A, Di Giovannantonio LG, Nusco E, Platt N, Guida A, Ogmundsdottir MH, Lanfrancone L, Perera RM, Zoncu R, Pelicci PG, Settembre C, Ballabio A. Di Malta C, et al. Among authors: zoncu r. Science. 2017 Jun 16;356(6343):1188-1192. doi: 10.1126/science.aag2553. Science. 2017. PMID: 28619945 Free PMC article.
Emerging Roles for the Lysosome in Lipid Metabolism.
Thelen AM, Zoncu R. Thelen AM, et al. Among authors: zoncu r. Trends Cell Biol. 2017 Nov;27(11):833-850. doi: 10.1016/j.tcb.2017.07.006. Epub 2017 Aug 30. Trends Cell Biol. 2017. PMID: 28838620 Free PMC article. Review.
75 results