Alter S - Search Results

1

Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model.

Mathios D, Park CK, Marcus WD, Alter S, Rhode PR, Jeng EK, Wong HC, Pardoll DM, Lim M. Mathios D, et al. Among authors: alter s. Int J Cancer. 2016 Jan 1;138(1):187-94. doi: 10.1002/ijc.29686. Epub 2015 Jul 28. Int J Cancer. 2016. PMID: 26174883 Free PMC article.

2

Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models.

Rhode PR, Egan JO, Xu W, Hong H, Webb GM, Chen X, Liu B, Zhu X, Wen J, You L, Kong L, Edwards AC, Han K, Shi S, Alter S, Sacha JB, Jeng EK, Cai W, Wong HC. Rhode PR, et al. Among authors: alter s. Cancer Immunol Res. 2016 Jan;4(1):49-60. doi: 10.1158/2326-6066.CIR-15-0093-T. Epub 2015 Oct 28. Cancer Immunol Res. 2016. PMID: 26511282 Free PMC article.

3

IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas.

Kim PS, Kwilas AR, Xu W, Alter S, Jeng EK, Wong HC, Schlom J, Hodge JW. Kim PS, et al. Among authors: alter s. Oncotarget. 2016 Mar 29;7(13):16130-45. doi: 10.18632/oncotarget.7470. Oncotarget. 2016. PMID: 26910920 Free PMC article.

4

A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody Demonstrates Antigen-specific Antitumor Responses.

Liu B, Kong L, Han K, Hong H, Marcus WD, Chen X, Jeng EK, Alter S, Zhu X, Rubinstein MP, Shi S, Rhode PR, Cai W, Wong HC. Liu B, et al. Among authors: alter s. J Biol Chem. 2016 Nov 11;291(46):23869-23881. doi: 10.1074/jbc.M116.733600. Epub 2016 Sep 20. J Biol Chem. 2016. PMID: 27650494 Free PMC article.

5

Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models.

Liu B, Jones M, Kong L, Noel T, Jeng EK, Shi S, England CG, Alter S, Miller JS, Cai W, Rhode PR, Wong HC. Liu B, et al. Among authors: alter s. Cytokine. 2018 Jul;107:105-112. doi: 10.1016/j.cyto.2017.12.003. Epub 2018 Feb 13. Cytokine. 2018. PMID: 29452720 Free PMC article.

6

Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.

Burrack KS, Huggins MA, Taras E, Dougherty P, Henzler CM, Yang R, Alter S, Jeng EK, Wong HC, Felices M, Cichocki F, Miller JS, Hart GT, Johnson AJ, Jameson SC, Hamilton SE. Burrack KS, et al. Among authors: alter s. Immunity. 2018 Apr 17;48(4):760-772.e4. doi: 10.1016/j.immuni.2018.03.012. Epub 2018 Apr 3. Immunity. 2018. PMID: 29625893 Free PMC article.

7

Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model.

Furuya H, Chan OTM, Pagano I, Zhu C, Kim N, Peres R, Hokutan K, Alter S, Rhode P, Rosser CJ. Furuya H, et al. Among authors: alter s. J Transl Med. 2019 Jan 17;17(1):29. doi: 10.1186/s12967-019-1778-6. J Transl Med. 2019. PMID: 30654801 Free PMC article.

8

Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy.

Knudson KM, Hicks KC, Alter S, Schlom J, Gameiro SR. Knudson KM, et al. Among authors: alter s. J Immunother Cancer. 2019 Mar 21;7(1):82. doi: 10.1186/s40425-019-0551-y. J Immunother Cancer. 2019. PMID: 30898149 Free PMC article.

9

In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells.

Ratliff M, Alter S, McAvoy K, Frasca D, Wright JA, Zinkel SS, Khan WN, Blomberg BB, Riley RL. Ratliff M, et al. Among authors: alter s. Aging Cell. 2015 Jun;14(3):382-90. doi: 10.1111/acel.12302. Epub 2015 Feb 27. Aging Cell. 2015. PMID: 25727904 Free PMC article.

10

In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors.

Ratliff M, Alter S, Frasca D, Blomberg BB, Riley RL. Ratliff M, et al. Among authors: alter s. Aging Cell. 2013 Apr;12(2):303-11. doi: 10.1111/acel.12055. Aging Cell. 2013. PMID: 23410004 Free PMC article.

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