Manova K - Search Results

1

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.

Meyer SC, Keller MD, Chiu S, Koppikar P, Guryanova OA, Rapaport F, Xu K, Manova K, Pankov D, O'Reilly RJ, Kleppe M, McKenney AS, Shih AH, Shank K, Ahn J, Papalexi E, Spitzer B, Socci N, Viale A, Mandon E, Ebel N, Andraos R, Rubert J, Dammassa E, Romanet V, Dölemeyer A, Zender M, Heinlein M, Rampal R, Weinberg RS, Hoffman R, Sellers WR, Hofmann F, Murakami M, Baffert F, Gaul C, Radimerski T, Levine RL. Meyer SC, et al. Among authors: manova k. Cancer Cell. 2015 Jul 13;28(1):15-28. doi: 10.1016/j.ccell.2015.06.006. Cancer Cell. 2015. PMID: 26175413 Free PMC article.

2

Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate.

Shaffer DR, Viale A, Ishiwata R, Leversha M, Olgac S, Manova K, Satagopan J, Scher H, Koff A. Shaffer DR, et al. Among authors: manova k. Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):210-5. doi: 10.1073/pnas.0407362102. Epub 2004 Dec 22. Proc Natl Acad Sci U S A. 2005. PMID: 15615849 Free PMC article.

3

Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor.

Rossi F, Ehlers I, Agosti V, Socci ND, Viale A, Sommer G, Yozgat Y, Manova K, Antonescu CR, Besmer P. Rossi F, et al. Among authors: manova k. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12843-8. doi: 10.1073/pnas.0511076103. Epub 2006 Aug 14. Proc Natl Acad Sci U S A. 2006. PMID: 16908864 Free PMC article.

4

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

Chang Q, Bournazou E, Sansone P, Berishaj M, Gao SP, Daly L, Wels J, Theilen T, Granitto S, Zhang X, Cotari J, Alpaugh ML, de Stanchina E, Manova K, Li M, Bonafe M, Ceccarelli C, Taffurelli M, Santini D, Altan-Bonnet G, Kaplan R, Norton L, Nishimoto N, Huszar D, Lyden D, Bromberg J. Chang Q, et al. Among authors: manova k. Neoplasia. 2013 Jul;15(7):848-62. doi: 10.1593/neo.13706. Neoplasia. 2013. PMID: 23814496 Free PMC article.

5

Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3^KLHL21 protein complex during abscission.

Huang G, Kaufman AJ, Xu K, Manova K, Singh B. Huang G, et al. Among authors: manova k. J Biol Chem. 2017 Sep 15;292(37):15254-15265. doi: 10.1074/jbc.M117.778530. Epub 2017 Jun 15. J Biol Chem. 2017. PMID: 28620047 Free PMC article.

6

The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa->luteal transition.

Tong W, Kiyokawa H, Soos TJ, Park MS, Soares VC, Manova K, Pollard JW, Koff A. Tong W, et al. Among authors: manova k. Cell Growth Differ. 1998 Sep;9(9):787-94. Cell Growth Differ. 1998. PMID: 9751122

7

Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts.

Lyden D, Young AZ, Zagzag D, Yan W, Gerald W, O'Reilly R, Bader BL, Hynes RO, Zhuang Y, Manova K, Benezra R. Lyden D, et al. Among authors: manova k. Nature. 1999 Oct 14;401(6754):670-7. doi: 10.1038/44334. Nature. 1999. PMID: 10537105

8

Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors.

Ruzinova MB, Schoer RA, Gerald W, Egan JE, Pandolfi PP, Rafii S, Manova K, Mittal V, Benezra R. Ruzinova MB, et al. Among authors: manova k. Cancer Cell. 2003 Oct;4(4):277-89. doi: 10.1016/s1535-6108(03)00240-x. Cancer Cell. 2003. PMID: 14585355 Free article.

9

Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib.

Rossi F, Yozgat Y, de Stanchina E, Veach D, Clarkson B, Manova K, Giancotti FG, Antonescu CR, Besmer P. Rossi F, et al. Among authors: manova k. Mol Cancer Res. 2010 Sep;8(9):1271-83. doi: 10.1158/1541-7786.MCR-10-0065. Epub 2010 Aug 24. Mol Cancer Res. 2010. PMID: 20736294 Free PMC article.

10

Iron deposition is associated with differential macrophage infiltration and therapeutic response to iron chelation in prostate cancer.

Leftin A, Zhao H, Turkekul M, de Stanchina E, Manova K, Koutcher JA. Leftin A, et al. Among authors: manova k. Sci Rep. 2017 Sep 14;7(1):11632. doi: 10.1038/s41598-017-11899-2. Sci Rep. 2017. PMID: 28912459 Free PMC article.

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