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AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy.
Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR. Spindler MJ, et al. Among authors: carnegie gk. PLoS One. 2013 Apr 26;8(4):e62705. doi: 10.1371/journal.pone.0062705. Print 2013. PLoS One. 2013. Retraction in: PLoS One. 2023 Dec 12;18(12):e0296004. doi: 10.1371/journal.pone.0296004 PMID: 23658642 Free PMC article. Retracted.
Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart.
Burmeister BT, Taglieri DM, Wang L, Carnegie GK. Burmeister BT, et al. Among authors: carnegie gk. J Biol Chem. 2012 Nov 23;287(48):40535-46. doi: 10.1074/jbc.M112.385641. Epub 2012 Oct 8. J Biol Chem. 2012. PMID: 23045525 Free PMC article.
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.
Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, Bristow MR, Kunkel MT, Newton AC, Langeberg LK, Scott JD. Carnegie GK, et al. Mol Cell. 2008 Oct 24;32(2):169-79. doi: 10.1016/j.molcel.2008.08.030. Mol Cell. 2008. PMID: 18951085 Free PMC article.
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