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TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2.
Venkatesan S, Hoogstraat M, Caljouw E, Pierson T, Spoor JK, Zeneyedpour L, Dubbink HJ, Dekker LJ, van der Kaaij M, Kloezeman J, Berghauser Pont LM, Besselink NJ, Luider TM, Joore J, Martens JW, Lamfers ML, Sleijfer S, Leenstra S. Venkatesan S, et al. Among authors: berghauser pont lm. Oncotarget. 2016 Sep 6;7(36):58435-58444. doi: 10.18632/oncotarget.11205. Oncotarget. 2016. PMID: 27533080 Free PMC article.
Currarino's triad diagnosed in an adult woman.
Berghauser Pont LM, Dirven CM, Dammers R. Berghauser Pont LM, et al. Eur Spine J. 2012 Jun;21 Suppl 4(Suppl 4):S569-72. doi: 10.1007/s00586-012-2311-2. Epub 2012 Apr 24. Eur Spine J. 2012. PMID: 22526704 Free PMC article.