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181 results

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Page 1
Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases.
Nettekoven M, Adam JM, Bendels S, Bissantz C, Fingerle J, Grether U, Grüner S, Guba W, Kimbara A, Ottaviani G, Püllmann B, Rogers-Evans M, Röver S, Rothenhäusler B, Schmitt S, Schuler F, Schulz-Gasch T, Ullmer C. Nettekoven M, et al. Among authors: schuler f. ChemMedChem. 2016 Jan 19;11(2):179-89. doi: 10.1002/cmdc.201500218. Epub 2015 Jul 21. ChemMedChem. 2016. PMID: 26228928
Highly potent and selective cannabinoid receptor 2 agonists: initial hit optimization of an adamantyl hit series identified from high-through-put screening.
Nettekoven M, Fingerle J, Grether U, Grüner S, Kimbara A, Püllmann B, Rogers-Evans M, Röver S, Schuler F, Schulz-Gasch T, Ullmer C. Nettekoven M, et al. Among authors: schuler f. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1177-81. doi: 10.1016/j.bmcl.2013.01.044. Epub 2013 Jan 23. Bioorg Med Chem Lett. 2013. PMID: 23380378
5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.
Pierson PD, Fettes A, Freichel C, Gatti-McArthur S, Hertel C, Huwyler J, Mohr P, Nakagawa T, Nettekoven M, Plancher JM, Raab S, Richter H, Roche O, Rodríguez Sarmiento RM, Schmitt M, Schuler F, Takahashi T, Taylor S, Ullmer C, Wiegand R. Pierson PD, et al. Among authors: schuler f. J Med Chem. 2009 Jul 9;52(13):3855-68. doi: 10.1021/jm900409x. J Med Chem. 2009. PMID: 19456097
Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties.
Richter HG, Benson GM, Bleicher KH, Blum D, Chaput E, Clemann N, Feng S, Gardes C, Grether U, Hartman P, Kuhn B, Martin RE, Plancher JM, Rudolph MG, Schuler F, Taylor S. Richter HG, et al. Among authors: schuler f. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1134-40. doi: 10.1016/j.bmcl.2010.12.123. Epub 2010 Dec 31. Bioorg Med Chem Lett. 2011. PMID: 21269824
Oxetanes in drug discovery: structural and synthetic insights.
Wuitschik G, Carreira EM, Wagner B, Fischer H, Parrilla I, Schuler F, Rogers-Evans M, Müller K. Wuitschik G, et al. Among authors: schuler f. J Med Chem. 2010 Apr 22;53(8):3227-46. doi: 10.1021/jm9018788. J Med Chem. 2010. PMID: 20349959
Oxetanes as promising modules in drug discovery.
Wuitschik G, Rogers-Evans M, Müller K, Fischer H, Wagner B, Schuler F, Polonchuk L, Carreira EM. Wuitschik G, et al. Among authors: schuler f. Angew Chem Int Ed Engl. 2006 Nov 27;45(46):7736-9. doi: 10.1002/anie.200602343. Angew Chem Int Ed Engl. 2006. PMID: 17013952 No abstract available.
Spirocyclic oxetanes: synthesis and properties.
Wuitschik G, Rogers-Evans M, Buckl A, Bernasconi M, Märki M, Godel T, Fischer H, Wagner B, Parrilla I, Schuler F, Schneider J, Alker A, Schweizer WB, Müller K, Carreira EM. Wuitschik G, et al. Among authors: schuler f. Angew Chem Int Ed Engl. 2008;47(24):4512-5. doi: 10.1002/anie.200800450. Angew Chem Int Ed Engl. 2008. PMID: 18465828 No abstract available.
181 results