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Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.
Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B. Nillegoda NB, et al. Among authors: morimoto ri. Nature. 2015 Aug 13;524(7564):247-51. doi: 10.1038/nature14884. Epub 2015 Aug 5. Nature. 2015. PMID: 26245380 Free PMC article.
Polyglutamine protein aggregates are dynamic.
Kim S, Nollen EA, Kitagawa K, Bindokas VP, Morimoto RI. Kim S, et al. Among authors: morimoto ri. Nat Cell Biol. 2002 Oct;4(10):826-31. doi: 10.1038/ncb863. Nat Cell Biol. 2002. PMID: 12360295
Small-molecule proteostasis regulators for protein conformational diseases.
Calamini B, Silva MC, Madoux F, Hutt DM, Khanna S, Chalfant MA, Saldanha SA, Hodder P, Tait BD, Garza D, Balch WE, Morimoto RI. Calamini B, et al. Among authors: morimoto ri. Nat Chem Biol. 2011 Dec 25;8(2):185-96. doi: 10.1038/nchembio.763. Nat Chem Biol. 2011. PMID: 22198733 Free PMC article.
Metazoan Hsp70 machines use Hsp110 to power protein disaggregation.
Rampelt H, Kirstein-Miles J, Nillegoda NB, Chi K, Scholz SR, Morimoto RI, Bukau B. Rampelt H, et al. Among authors: morimoto ri. EMBO J. 2012 Nov 5;31(21):4221-35. doi: 10.1038/emboj.2012.264. Epub 2012 Sep 18. EMBO J. 2012. PMID: 22990239 Free PMC article.
285 results