Lefebvre E - Search Results

1

Cenicriviroc, a Novel CCR5 (R5) and CCR2 Antagonist, Shows In Vitro Activity against R5 Tropic HIV-2 Clinical Isolates.

Visseaux B, Charpentier C, Collin G, Bertine M, Peytavin G, Damond F, Matheron S, Lefebvre E, Brun-Vézinet F, Descamps D; ANRS CO5 HIV-2 Cohort. Visseaux B, et al. Among authors: lefebvre e. PLoS One. 2015 Aug 6;10(8):e0134904. doi: 10.1371/journal.pone.0134904. eCollection 2015. PLoS One. 2015. PMID: 26247470 Free PMC article.

2

Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis.

Lefebvre E, Moyle G, Reshef R, Richman LP, Thompson M, Hong F, Chou HL, Hashiguchi T, Plato C, Poulin D, Richards T, Yoneyama H, Jenkins H, Wolfgang G, Friedman SL. Lefebvre E, et al. PLoS One. 2016 Jun 27;11(6):e0158156. doi: 10.1371/journal.pone.0158156. eCollection 2016. PLoS One. 2016. PMID: 27347680 Free PMC article.

3

Differential impact of the dual CCR2/CCR5 inhibitor cenicriviroc on migration of monocyte and lymphocyte subsets in acute liver injury.

Puengel T, Krenkel O, Kohlhepp M, Lefebvre E, Luedde T, Trautwein C, Tacke F. Puengel T, et al. Among authors: lefebvre e. PLoS One. 2017 Sep 14;12(9):e0184694. doi: 10.1371/journal.pone.0184694. eCollection 2017. PLoS One. 2017. PMID: 28910354 Free PMC article.

4

Pharmacokinetics, Safety, and CCR2/CCR5 Antagonist Activity of Cenicriviroc in Participants With Mild or Moderate Hepatic Impairment.

Lefebvre E, Gottwald M, Lasseter K, Chang W, Willett M, Smith PF, Somasunderam A, Utay NS. Lefebvre E, et al. Clin Transl Sci. 2016 Jun;9(3):139-48. doi: 10.1111/cts.12397. Epub 2016 May 12. Clin Transl Sci. 2016. PMID: 27169903 Free PMC article. Clinical Trial.

5

The dual CCR5 and CCR2 inhibitor cenicriviroc does not redistribute HIV into extracellular space: implications for plasma viral load and intracellular DNA decline.

Kramer VG, Hassounah S, Colby-Germinario SP, Oliveira M, Lefebvre E, Mesplède T, Wainberg MA. Kramer VG, et al. Among authors: lefebvre e. J Antimicrob Chemother. 2015 Mar;70(3):750-6. doi: 10.1093/jac/dku451. Epub 2014 Nov 27. J Antimicrob Chemother. 2015. PMID: 25433008

6

Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism.

DʼAntoni ML, Paul RH, Mitchell BI, Kohorn L, Fischer L, Lefebvre E, Seyedkazemi S, Nakamoto BK, Walker M, Kallianpur KJ, Ogata-Arakaki D, Ndhlovu LC, Shikuma C. DʼAntoni ML, et al. Among authors: lefebvre e. J Acquir Immune Defic Syndr. 2018 Sep 1;79(1):108-116. doi: 10.1097/QAI.0000000000001752. J Acquir Immune Defic Syndr. 2018. PMID: 29781885 Free PMC article. Clinical Trial.

7

A 48-week randomized phase 2b study evaluating cenicriviroc versus efavirenz in treatment-naive HIV-infected adults with C-C chemokine receptor type 5-tropic virus.

Thompson M, Saag M, DeJesus E, Gathe J, Lalezari J, Landay AL, Cade J, Enejosa J, Lefebvre E, Feinberg J. Thompson M, et al. Among authors: lefebvre e. AIDS. 2016 Mar 27;30(6):869-78. doi: 10.1097/QAD.0000000000000988. AIDS. 2016. PMID: 26636929 Free PMC article. Clinical Trial.

8

Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design.

Friedman S, Sanyal A, Goodman Z, Lefebvre E, Gottwald M, Fischer L, Ratziu V. Friedman S, et al. Among authors: lefebvre e. Contemp Clin Trials. 2016 Mar;47:356-65. doi: 10.1016/j.cct.2016.02.012. Epub 2016 Mar 2. Contemp Clin Trials. 2016. PMID: 26944023 Free article. Clinical Trial.

9

Cenicriviroc blocks HIV entry but does not lead to redistribution of HIV into extracellular space like maraviroc.

Kramer V, Hassounah S, Colby-Germinario S, Mesplède T, Lefebvre E, Wainberg M. Kramer V, et al. Among authors: lefebvre e. J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19531. doi: 10.7448/IAS.17.4.19531. eCollection 2014. J Int AIDS Soc. 2014. PMID: 25394040 Free PMC article.

10

Cenicriviroc inhibits trans-endothelial passage of monocytes and is associated with impaired E-selectin expression.

D'Antoni ML, Mitchell BI, McCurdy S, Byron MM, Ogata-Arakaki D, Chow D, Mehta NN, Boisvert WA, Lefebvre E, Shikuma CM, Ndhlovu LC, Baumer Y. D'Antoni ML, et al. Among authors: lefebvre e. J Leukoc Biol. 2018 Dec;104(6):1241-1252. doi: 10.1002/JLB.5A0817-328RRR. Epub 2018 Aug 8. J Leukoc Biol. 2018. PMID: 30088682 Free PMC article.

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