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A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma.
Ko AH, Bekaii-Saab T, Van Ziffle J, Mirzoeva OM, Joseph NM, Talasaz A, Kuhn P, Tempero MA, Collisson EA, Kelley RK, Venook AP, Dito E, Ong A, Ziyeh S, Courtin R, Linetskaya R, Tahiri S, Korn WM. Ko AH, et al. Among authors: joseph nm. Clin Cancer Res. 2016 Jan 1;22(1):61-8. doi: 10.1158/1078-0432.CCR-15-0979. Epub 2015 Aug 6. Clin Cancer Res. 2016. PMID: 26251290 Free PMC article. Clinical Trial.
Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity.
Liu SY, Joseph NM, Ravindranathan A, Stohr BA, Greenland NY, Vohra P, Hosfield E, Yeh I, Talevich E, Onodera C, Van Ziffle JA, Grenert JP, Bastian BC, Chen YY, Krings G. Liu SY, et al. Among authors: joseph nm. Mod Pathol. 2016 Sep;29(9):1012-27. doi: 10.1038/modpathol.2016.97. Epub 2016 Jun 3. Mod Pathol. 2016. PMID: 27255162 Free article.
Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation.
Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT. Phillips JJ, et al. Among authors: joseph nm. Acta Neuropathol. 2016 Nov;132(5):757-760. doi: 10.1007/s00401-016-1616-3. Epub 2016 Sep 13. Acta Neuropathol. 2016. PMID: 27624885 Free PMC article. No abstract available.
Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.
Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Kline CN, et al. Among authors: joseph nm. Neuro Oncol. 2017 May 1;19(5):699-709. doi: 10.1093/neuonc/now254. Neuro Oncol. 2017. PMID: 28453743 Free PMC article.
Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation.
Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian BC, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon DA. Goode B, et al. Among authors: joseph nm. Mod Pathol. 2018 Apr;31(4):660-673. doi: 10.1038/modpathol.2017.153. Epub 2017 Nov 17. Mod Pathol. 2018. PMID: 29148537 Free PMC article.
The genetic landscape of anaplastic pleomorphic xanthoastrocytoma.
Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh JTC, Solomon DA. Phillips JJ, et al. Among authors: joseph nm. Brain Pathol. 2019 Jan;29(1):85-96. doi: 10.1111/bpa.12639. Epub 2018 Nov 6. Brain Pathol. 2019. PMID: 30051528 Free PMC article.
Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix.
Jiang H, Torphy RJ, Steiger K, Hongo H, Ritchie AJ, Kriegsmann M, Horst D, Umetsu SE, Joseph NM, McGregor K, Pishvaian MJ, Blais EM, Lu B, Li M, Hollingsworth M, Stashko C, Volmar K, Yeh JJ, Weaver VM, Wang ZJ, Tempero MA, Weichert W, Collisson EA. Jiang H, et al. Among authors: joseph nm. J Clin Invest. 2020 Sep 1;130(9):4704-4709. doi: 10.1172/JCI136760. J Clin Invest. 2020. PMID: 32749238 Free PMC article.
APOBEC Mutational Signature and Tumor Mutational Burden as Predictors of Clinical Outcomes and Treatment Response in Patients With Advanced Urothelial Cancer.
Natesan D, Zhang L, Martell HJ, Jindal T, Devine P, Stohr B, Espinosa-Mendez C, Grenert J, Van Ziffle J, Joseph N, Umetsu S, Onodera C, Turski M, Chan E, Desai A, Aggarwal R, Wong A, Porten S, Chou J, Friedlander T, Fong L, Small EJ, Sweet-Cordero A, Koshkin VS. Natesan D, et al. Front Oncol. 2022 Mar 7;12:816706. doi: 10.3389/fonc.2022.816706. eCollection 2022. Front Oncol. 2022. PMID: 35321431 Free PMC article.
182 results