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Page 1
Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.
Zalachoras I, Houtman R, Atucha E, Devos R, Tijssen AM, Hu P, Lockey PM, Datson NA, Belanoff JK, Lucassen PJ, Joëls M, de Kloet ER, Roozendaal B, Hunt H, Meijer OC. Zalachoras I, et al. Among authors: belanoff jk. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7910-5. doi: 10.1073/pnas.1219411110. Epub 2013 Apr 23. Proc Natl Acad Sci U S A. 2013. PMID: 23613579 Free PMC article.
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals.
Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. Vendruscolo LF, et al. Among authors: belanoff jk. J Clin Invest. 2015 Aug 3;125(8):3193-7. doi: 10.1172/JCI79828. Epub 2015 Jun 29. J Clin Invest. 2015. PMID: 26121746 Free PMC article. Clinical Trial.
Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation.
van den Heuvel JK, Boon MR, van Hengel I, Peschier-van der Put E, van Beek L, van Harmelen V, van Dijk KW, Pereira AM, Hunt H, Belanoff JK, Rensen PC, Meijer OC. van den Heuvel JK, et al. Among authors: belanoff jk. Br J Pharmacol. 2016 Jun;173(11):1793-804. doi: 10.1111/bph.13477. Epub 2016 Apr 24. Br J Pharmacol. 2016. PMID: 26990179 Free PMC article.
Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction.
Teich T, Dunford EC, Porras DP, Pivovarov JA, Beaudry JL, Hunt H, Belanoff JK, Riddell MC. Teich T, et al. Among authors: belanoff jk. Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E56-68. doi: 10.1152/ajpendo.00490.2015. Epub 2016 May 3. Am J Physiol Endocrinol Metab. 2016. PMID: 27143556 Free PMC article.
Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.
Hunt HJ, Belanoff JK, Walters I, Gourdet B, Thomas J, Barton N, Unitt J, Phillips T, Swift D, Eaton E. Hunt HJ, et al. Among authors: belanoff jk. J Med Chem. 2017 Apr 27;60(8):3405-3421. doi: 10.1021/acs.jmedchem.7b00162. Epub 2017 Apr 17. J Med Chem. 2017. PMID: 28368581
48 results