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Asparagine Synthetase Deficiency causes reduced proliferation of cells under conditions of limited asparagine.
Palmer EE, Hayner J, Sachdev R, Cardamone M, Kandula T, Morris P, Dias KR, Tao J, Miller D, Zhu Y, Macintosh R, Dinger ME, Cowley MJ, Buckley MF, Roscioli T, Bye A, Kilberg MS, Kirk EP. Palmer EE, et al. Among authors: kilberg ms. Mol Genet Metab. 2015 Nov;116(3):178-86. doi: 10.1016/j.ymgme.2015.08.007. Epub 2015 Aug 14. Mol Genet Metab. 2015. PMID: 26318253 Free PMC article.
Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency.
Sacharow SJ, Dudenhausen EE, Lomelino CL, Rodan L, El Achkar CM, Olson HE, Genetti CA, Agrawal PB, McKenna R, Kilberg MS. Sacharow SJ, et al. Among authors: kilberg ms. Mol Genet Metab. 2018 Mar;123(3):317-325. doi: 10.1016/j.ymgme.2017.12.433. Epub 2017 Dec 20. Mol Genet Metab. 2018. PMID: 29279279 Free PMC article.
Asparagine synthetase: Function, structure, and role in disease.
Lomelino CL, Andring JT, McKenna R, Kilberg MS. Lomelino CL, et al. Among authors: kilberg ms. J Biol Chem. 2017 Dec 8;292(49):19952-19958. doi: 10.1074/jbc.R117.819060. Epub 2017 Oct 30. J Biol Chem. 2017. PMID: 29084849 Free PMC article. Review.
A mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-dependent transcriptional program controls activation of the early growth response 1 (EGR1) gene during amino acid limitation.
Shan J, Balasubramanian MN, Donelan W, Fu L, Hayner J, Lopez MC, Baker HV, Kilberg MS. Shan J, et al. Among authors: kilberg ms. J Biol Chem. 2014 Aug 29;289(35):24665-79. doi: 10.1074/jbc.M114.565028. Epub 2014 Jul 15. J Biol Chem. 2014. PMID: 25028509 Free PMC article.
166 results