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Page 1
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.
Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJ, Tonc E, Schreiber RD, Pearce EJ, Pearce EL. Chang CH, et al. Among authors: pearce ej, pearce el. Cell. 2015 Sep 10;162(6):1229-41. doi: 10.1016/j.cell.2015.08.016. Epub 2015 Aug 27. Cell. 2015. PMID: 26321679 Free PMC article.
Posttranscriptional control of T cell effector function by aerobic glycolysis.
Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL. Chang CH, et al. Among authors: pearce ej, pearce el. Cell. 2013 Jun 6;153(6):1239-51. doi: 10.1016/j.cell.2013.05.016. Cell. 2013. PMID: 23746840 Free PMC article.
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.
Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL. Buck MD, et al. Among authors: pearce ej, pearce el. Cell. 2016 Jun 30;166(1):63-76. doi: 10.1016/j.cell.2016.05.035. Epub 2016 Jun 9. Cell. 2016. PMID: 27293185 Free PMC article.
Acetate Promotes T Cell Effector Function during Glucose Restriction.
Qiu J, Villa M, Sanin DE, Buck MD, O'Sullivan D, Ching R, Matsushita M, Grzes KM, Winkler F, Chang CH, Curtis JD, Kyle RL, Van Teijlingen Bakker N, Corrado M, Haessler F, Alfei F, Edwards-Hicks J, Maggi LB Jr, Zehn D, Egawa T, Bengsch B, Klein Geltink RI, Jenuwein T, Pearce EJ, Pearce EL. Qiu J, et al. Among authors: pearce ej, pearce el. Cell Rep. 2019 May 14;27(7):2063-2074.e5. doi: 10.1016/j.celrep.2019.04.022. Cell Rep. 2019. PMID: 31091446 Free PMC article.
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability.
van der Windt GJ, O'Sullivan D, Everts B, Huang SC, Buck MD, Curtis JD, Chang CH, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL. van der Windt GJ, et al. Among authors: pearce ej, pearce el. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14336-41. doi: 10.1073/pnas.1221740110. Epub 2013 Aug 12. Proc Natl Acad Sci U S A. 2013. PMID: 23940348 Free PMC article.
Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.
O'Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL. O'Sullivan D, et al. Among authors: pearce ej, pearce el. Immunity. 2014 Jul 17;41(1):75-88. doi: 10.1016/j.immuni.2014.06.005. Epub 2014 Jul 4. Immunity. 2014. PMID: 25001241 Free PMC article.
Mitochondrial Priming by CD28.
Klein Geltink RI, O'Sullivan D, Corrado M, Bremser A, Buck MD, Buescher JM, Firat E, Zhu X, Niedermann G, Caputa G, Kelly B, Warthorst U, Rensing-Ehl A, Kyle RL, Vandersarren L, Curtis JD, Patterson AE, Lawless S, Grzes K, Qiu J, Sanin DE, Kretz O, Huber TB, Janssens S, Lambrecht BN, Rambold AS, Pearce EJ, Pearce EL. Klein Geltink RI, et al. Among authors: pearce ej, pearce el. Cell. 2017 Oct 5;171(2):385-397.e11. doi: 10.1016/j.cell.2017.08.018. Epub 2017 Sep 14. Cell. 2017. PMID: 28919076 Free PMC article.
Metabolic interventions in the immune response to cancer.
O'Sullivan D, Sanin DE, Pearce EJ, Pearce EL. O'Sullivan D, et al. Among authors: pearce ej, pearce el. Nat Rev Immunol. 2019 May;19(5):324-335. doi: 10.1038/s41577-019-0140-9. Nat Rev Immunol. 2019. PMID: 30820043 Review.
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.
Puleston DJ, Buck MD, Klein Geltink RI, Kyle RL, Caputa G, O'Sullivan D, Cameron AM, Castoldi A, Musa Y, Kabat AM, Zhang Y, Flachsmann LJ, Field CS, Patterson AE, Scherer S, Alfei F, Baixauli F, Austin SK, Kelly B, Matsushita M, Curtis JD, Grzes KM, Villa M, Corrado M, Sanin DE, Qiu J, Pällman N, Paz K, Maccari ME, Blazar BR, Mittler G, Buescher JM, Zehn D, Rospert S, Pearce EJ, Balabanov S, Pearce EL. Puleston DJ, et al. Among authors: pearce ej, pearce el. Cell Metab. 2019 Aug 6;30(2):352-363.e8. doi: 10.1016/j.cmet.2019.05.003. Epub 2019 May 23. Cell Metab. 2019. PMID: 31130465 Free PMC article.
255 results