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MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia.
Jones CL, Gearheart CM, Fosmire S, Delgado-Martin C, Evensen NA, Bride K, Waanders AJ, Pais F, Wang J, Bhatla T, Bitterman DS, de Rijk SR, Bourgeois W, Dandekar S, Park E, Burleson TM, Madhusoodhan PP, Teachey DT, Raetz EA, Hermiston ML, Müschen M, Loh ML, Hunger SP, Zhang J, Garabedian MJ, Porter CC, Carroll WL. Jones CL, et al. Among authors: bhatla t. Blood. 2015 Nov 5;126(19):2202-12. doi: 10.1182/blood-2015-04-639138. Epub 2015 Aug 31. Blood. 2015. PMID: 26324703 Free PMC article. Clinical Trial.
Endogenous knockdown of survivin improves chemotherapeutic response in ALL models.
Morrison DJ, Hogan LE, Condos G, Bhatla T, Germino N, Moskowitz NP, Lee L, Bhojwani D, Horton TM, Belitskaya-Levy I, Greenberger LM, Horak ID, Grupp SA, Teachey DT, Raetz EA, Carroll WL. Morrison DJ, et al. Among authors: bhatla t. Leukemia. 2012 Feb;26(2):271-9. doi: 10.1038/leu.2011.199. Epub 2011 Aug 16. Leukemia. 2012. PMID: 21844871 Free PMC article.
Loss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model.
Jones CL, Bhatla T, Blum R, Wang J, Paugh SW, Wen X, Bourgeois W, Bitterman DS, Raetz EA, Morrison DJ, Teachey DT, Evans WE, Garabedian MJ, Carroll WL. Jones CL, et al. Among authors: bhatla t. J Biol Chem. 2014 Jul 25;289(30):20502-15. doi: 10.1074/jbc.M114.569889. J Biol Chem. 2014. PMID: 24895125 Free PMC article. Clinical Trial.
Ikaros deletions in BCR-ABL-negative childhood acute lymphoblastic leukemia are associated with a distinct gene expression signature but do not result in intrinsic chemoresistance.
Vitanza NA, Zaky W, Blum R, Meyer JA, Wang J, Bhatla T, Morrison DJ, Raetz EA, Carroll WL. Vitanza NA, et al. Among authors: bhatla t. Pediatr Blood Cancer. 2014 Oct;61(10):1779-85. doi: 10.1002/pbc.25119. Epub 2014 Jun 29. Pediatr Blood Cancer. 2014. PMID: 24976218 Free PMC article.
27 results