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A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.
Neumann U, Rueeger H, Machauer R, Veenstra SJ, Lueoend RM, Tintelnot-Blomley M, Laue G, Beltz K, Vogg B, Schmid P, Frieauff W, Shimshek DR, Staufenbiel M, Jacobson LH. Neumann U, et al. Among authors: jacobson lh. Mol Neurodegener. 2015 Sep 3;10:44. doi: 10.1186/s13024-015-0033-8. Mol Neurodegener. 2015. PMID: 26336937 Free PMC article.
Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation.
Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan ZX, Roth K, Aguzzi A, Staufenbiel M, Walker LC, Jucker M. Eisele YS, et al. Among authors: jacobson lh. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12926-31. doi: 10.1073/pnas.0903200106. Epub 2009 Jul 21. Proc Natl Acad Sci U S A. 2009. PMID: 19622727 Free PMC article.
The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.
Wiessner C, Wiederhold KH, Tissot AC, Frey P, Danner S, Jacobson LH, Jennings GT, Lüönd R, Ortmann R, Reichwald J, Zurini M, Mir A, Bachmann MF, Staufenbiel M. Wiessner C, et al. Among authors: jacobson lh. J Neurosci. 2011 Jun 22;31(25):9323-31. doi: 10.1523/JNEUROSCI.0293-11.2011. J Neurosci. 2011. PMID: 21697382 Free PMC article.
BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system.
Mattsson N, Rajendran L, Zetterberg H, Gustavsson M, Andreasson U, Olsson M, Brinkmalm G, Lundkvist J, Jacobson LH, Perrot L, Neumann U, Borghys H, Mercken M, Dhuyvetter D, Jeppsson F, Blennow K, Portelius E. Mattsson N, et al. Among authors: jacobson lh. PLoS One. 2012;7(2):e31084. doi: 10.1371/journal.pone.0031084. Epub 2012 Feb 6. PLoS One. 2012. PMID: 22328928 Free PMC article.
Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides.
Rueeger H, Lueoend R, Machauer R, Veenstra SJ, Jacobson LH, Staufenbiel M, Desrayaud S, Rondeau JM, Möbitz H, Neumann U. Rueeger H, et al. Among authors: jacobson lh. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5300-6. doi: 10.1016/j.bmcl.2013.07.071. Epub 2013 Aug 9. Bioorg Med Chem Lett. 2013. PMID: 23981898
Distinct effects of IPSU and suvorexant on mouse sleep architecture.
Hoyer D, Dürst T, Fendt M, Jacobson LH, Betschart C, Hintermann S, Behnke D, Cotesta S, Laue G, Ofner S, Legangneux E, Gee CE. Hoyer D, et al. Among authors: jacobson lh. Front Neurosci. 2013 Dec 10;7:235. doi: 10.3389/fnins.2013.00235. eCollection 2013. Front Neurosci. 2013. PMID: 24368893 Free PMC article.
Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors.
Callander GE, Olorunda M, Monna D, Schuepbach E, Langenegger D, Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Laue G, Ofner S, Briard E, Gee CE, Jacobson LH, Hoyer D. Callander GE, et al. Among authors: jacobson lh. Front Neurosci. 2013 Dec 3;7:230. doi: 10.3389/fnins.2013.00230. eCollection 2013. Front Neurosci. 2013. PMID: 24376396 Free PMC article.
Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).
Behnke D, Cotesta S, Hintermann S, Fendt M, Gee CE, Jacobson LH, Laue G, Meyer A, Wagner T, Badiger S, Chaudhari V, Chebrolu M, Pandit C, Hoyer D, Betschart C. Behnke D, et al. Among authors: jacobson lh. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5555-60. doi: 10.1016/j.bmcl.2015.10.055. Epub 2015 Oct 19. Bioorg Med Chem Lett. 2015. PMID: 26522950
74 results