Blaney J - Search Results

1

Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors.

Burdick DJ, Wang S, Heise C, Pan B, Drummond J, Yin J, Goeser L, Magnuson S, Blaney J, Moffat J, Wang W, Chen H. Burdick DJ, et al. Among authors: blaney j. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4728-4732. doi: 10.1016/j.bmcl.2015.08.048. Epub 2015 Aug 22. Bioorg Med Chem Lett. 2015. PMID: 26338362

2

Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.

Hanan EJ, van Abbema A, Barrett K, Blair WS, Blaney J, Chang C, Eigenbrot C, Flynn S, Gibbons P, Hurley CA, Kenny JR, Kulagowski J, Lee L, Magnuson SR, Morris C, Murray J, Pastor RM, Rawson T, Siu M, Ultsch M, Zhou A, Sampath D, Lyssikatos JP. Hanan EJ, et al. Among authors: blaney j. J Med Chem. 2012 Nov 26;55(22):10090-107. doi: 10.1021/jm3012239. Epub 2012 Oct 24. J Med Chem. 2012. PMID: 23061660

3

Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.

Antonysamy SS, Aubol B, Blaney J, Browner MF, Giannetti AM, Harris SF, Hébert N, Hendle J, Hopkins S, Jefferson E, Kissinger C, Leveque V, Marciano D, McGee E, Nájera I, Nolan B, Tomimoto M, Torres E, Wright T. Antonysamy SS, et al. Among authors: blaney j. Bioorg Med Chem Lett. 2008 May 1;18(9):2990-5. doi: 10.1016/j.bmcl.2008.03.056. Epub 2008 Mar 22. Bioorg Med Chem Lett. 2008. PMID: 18400495

4

An integrated suite of modeling tools that empower scientists in structure- and property-based drug design.

Feng JA, Aliagas I, Bergeron P, Blaney JM, Bradley EK, Koehler MF, Lee ML, Ortwine DF, Tsui V, Wu J, Gobbi A. Feng JA, et al. Among authors: blaney jm. J Comput Aided Mol Des. 2015 Jun;29(6):511-23. doi: 10.1007/s10822-015-9845-4. Epub 2015 Apr 29. J Comput Aided Mol Des. 2015. PMID: 25921252

5

Measuring diversity: experimental design of combinatorial libraries for drug discovery.

Martin EJ, Blaney JM, Siani MA, Spellmeyer DC, Wong AK, Moos WH. Martin EJ, et al. Among authors: blaney jm. J Med Chem. 1995 Apr 28;38(9):1431-6. doi: 10.1021/jm00009a003. J Med Chem. 1995. PMID: 7739001

6

Enabling drug discovery project decisions with integrated computational chemistry and informatics.

Tsui V, Ortwine DF, Blaney JM. Tsui V, et al. J Comput Aided Mol Des. 2017 Mar;31(3):287-291. doi: 10.1007/s10822-016-9988-y. Epub 2016 Oct 31. J Comput Aided Mol Des. 2017. PMID: 27796615

7

Learning Medicinal Chemistry Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Rules from Cross-Company Matched Molecular Pairs Analysis (MMPA).

Kramer C, Ting A, Zheng H, Hert J, Schindler T, Stahl M, Robb G, Crawford JJ, Blaney J, Montague S, Leach AG, Dossetter AG, Griffen EJ. Kramer C, et al. Among authors: blaney j. J Med Chem. 2018 Apr 26;61(8):3277-3292. doi: 10.1021/acs.jmedchem.7b00935. Epub 2017 Sep 28. J Med Chem. 2018. PMID: 28956609

8

A very short history of structure-based design: how did we get here and where do we need to go?

Blaney J. Blaney J. J Comput Aided Mol Des. 2012 Jan;26(1):13-4. doi: 10.1007/s10822-011-9518-x. Epub 2011 Dec 11. J Comput Aided Mol Des. 2012. PMID: 22160556 No abstract available.

9

Quantitative structure-activity relationship of 5-(X-benzyl)-2,4-diaminopyrimidines inhibiting bovine liver dihydrofolate reductase.

Blaney JM, Dietrich SW, Reynolds MA, Hansch C. Blaney JM, et al. J Med Chem. 1979 Jun;22(6):614-7. doi: 10.1021/jm00192a003. J Med Chem. 1979. PMID: 458817

10

Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines.

Dietrich SW, Blaney JM, Reynolds MA, Jow PY, Hansch C. Dietrich SW, et al. Among authors: blaney jm. J Med Chem. 1980 Nov;23(11):1205-12. doi: 10.1021/jm00185a011. J Med Chem. 1980. PMID: 7005446

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