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IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.
Becker A, Eichentopf R, Sedlmeier R, Waniek A, Cynis H, Koch B, Stephan A, Bäuscher C, Kohlmann S, Hoffmann T, Kehlen A, Berg S, Freyse EJ, Osmand A, Plank AC, Roßner S, von Hörsten S, Graubner S, Demuth HU, Schilling S. Becker A, et al. Among authors: von horsten s. Biol Chem. 2016 Jan;397(1):45-55. doi: 10.1515/hsz-2015-0192. Biol Chem. 2016. PMID: 26351917
Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
Schilling S, Kohlmann S, Bäuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hörsten S, Rossner S, Graubner S, Demuth HU. Schilling S, et al. Among authors: von horsten s. J Biol Chem. 2011 Apr 22;286(16):14199-208. doi: 10.1074/jbc.M111.229385. Epub 2011 Feb 17. J Biol Chem. 2011. PMID: 21330373 Free PMC article.
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.
Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Rönicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rübsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth HU, von Hörsten S. Alexandru A, et al. Among authors: von horsten s. J Neurosci. 2011 Sep 7;31(36):12790-801. doi: 10.1523/JNEUROSCI.1794-11.2011. J Neurosci. 2011. PMID: 21900558 Free PMC article.
Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro.
Köppen J, Schulze A, Machner L, Wermann M, Eichentopf R, Guthardt M, Hähnel A, Klehm J, Kriegeskorte MC, Hartlage-Rübsamen M, Morawski M, von Hörsten S, Demuth HU, Roßner S, Schilling S. Köppen J, et al. Among authors: von horsten s. Molecules. 2020 Jan 29;25(3):580. doi: 10.3390/molecules25030580. Molecules. 2020. PMID: 32013170 Free PMC article.
A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.
Hartlage-Rübsamen M, Bluhm A, Moceri S, Machner L, Köppen J, Schenk M, Hilbrich I, Holzer M, Weidenfeller M, Richter F, Coras R, Serrano GE, Beach TG, Schilling S, von Hörsten S, Xiang W, Schulze A, Roßner S. Hartlage-Rübsamen M, et al. Among authors: von horsten s. Acta Neuropathol. 2021 Sep;142(3):399-421. doi: 10.1007/s00401-021-02349-5. Epub 2021 Jul 26. Acta Neuropathol. 2021. PMID: 34309760 Free PMC article.
Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer's disease.
Hartlage-Rübsamen M, Ratz V, Zeitschel U, Finzel L, Machner L, Köppen J, Schulze A, Demuth HU, von Hörsten S, Höfling C, Roßner S. Hartlage-Rübsamen M, et al. Among authors: von horsten s. Acta Neuropathol Commun. 2019 May 20;7(1):79. doi: 10.1186/s40478-019-0726-2. Acta Neuropathol Commun. 2019. PMID: 31109380 Free PMC article.
190 results