Ambaye ND - Search Results

1

Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.

Watson GM, Gunzburg MJ, Ambaye ND, Lucas WA, Traore DA, Kulkarni K, Cergol KM, Payne RJ, Panjikar S, Pero SC, Perlmutter P, Wilce MC, Wilce JA. Watson GM, et al. Among authors: ambaye nd. J Med Chem. 2015 Oct 8;58(19):7707-18. doi: 10.1021/acs.jmedchem.5b00609. Epub 2015 Sep 23. J Med Chem. 2015. PMID: 26359549

2

Benzopyrazine derivatives: A novel class of growth factor receptor bound protein 7 antagonists.

Ambaye ND, Gunzburg MJ, Lim RC, Price JT, Wilce MC, Wilce JA. Ambaye ND, et al. Bioorg Med Chem. 2011 Jan 1;19(1):693-701. doi: 10.1016/j.bmc.2010.10.030. Epub 2010 Oct 19. Bioorg Med Chem. 2011. PMID: 21134757

3

Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression.

Ambaye ND, Pero SC, Gunzburg MJ, Yap M, Clayton DJ, Del Borgo MP, Perlmutter P, Aguilar MI, Shukla GS, Peletskaya E, Cookson MM, Krag DN, Wilce MC, Wilce JA. Ambaye ND, et al. J Mol Biol. 2011 Sep 23;412(3):397-411. doi: 10.1016/j.jmb.2011.07.030. Epub 2011 Jul 23. J Mol Biol. 2011. PMID: 21802427

4

The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents.

Ambaye ND, Gunzburg MJ, Lim RC, Price JT, Wilce MC, Wilce JA. Ambaye ND, et al. ChemMedChem. 2013 Feb;8(2):280-8. doi: 10.1002/cmdc.201200400. Epub 2012 Dec 17. ChemMedChem. 2013. PMID: 23355456

5

Design and testing of bicyclic inhibitors of Grb7--are two cycles better than one?

Gunzburg MJ, Ambaye ND, Del Borgo MP, Perlmutter P, Wilce JA. Gunzburg MJ, et al. Among authors: ambaye nd. Biopolymers. 2013 Sep;100(5):543-9. doi: 10.1002/bip.22237. Biopolymers. 2013. PMID: 23505041

6

Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist.

Ambaye ND, Gunzburg MJ, Traore DA, Del Borgo MP, Perlmutter P, Wilce MC, Wilce JA. Ambaye ND, et al. Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):182-6. doi: 10.1107/S2053230X13033414. Epub 2014 Jan 21. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24637751 Free PMC article.

7

Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.

Gunzburg MJ, Kulkarni K, Watson GM, Ambaye ND, Del Borgo MP, Brandt R, Pero SC, Perlmutter P, Wilce MC, Wilce JA. Gunzburg MJ, et al. Among authors: ambaye nd. Sci Rep. 2016 Jun 3;6:27060. doi: 10.1038/srep27060. Sci Rep. 2016. PMID: 27257138 Free PMC article.

8

Uptake of a cell permeable G7-18NATE contruct into cells and binding with the Grb-7-SH2 domain.

Ambaye ND, Lim RC, Clayton DJ, Gunzburg MJ, Price JT, Pero SC, Krag DN, Wilce MC, Aguilar MI, Perlmutter P, Wilce JA. Ambaye ND, et al. Biopolymers. 2011;96(2):181-8. doi: 10.1002/bip.21403. Biopolymers. 2011. PMID: 20564009

9

Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity.

Gunzburg MJ, Ambaye ND, Del Borgo MP, Pero SC, Krag DN, Wilce MC, Wilce JA. Gunzburg MJ, et al. Among authors: ambaye nd. J Mol Recognit. 2012 Jan;25(1):57-67. doi: 10.1002/jmr.2148. J Mol Recognit. 2012. PMID: 22213451

10

Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.

Actis ML, Ambaye ND, Evison BJ, Shao Y, Vanarotti M, Inoue A, McDonald ET, Kikuchi S, Heath R, Hara K, Hashimoto H, Fujii N. Actis ML, et al. Among authors: ambaye nd. Bioorg Med Chem. 2016 Sep 15;24(18):4339-4346. doi: 10.1016/j.bmc.2016.07.026. Epub 2016 Jul 16. Bioorg Med Chem. 2016. PMID: 27448776 Free PMC article.

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