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Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198.
Molenaar RJ, Botman D, Smits MA, Hira VV, van Lith SA, Stap J, Henneman P, Khurshed M, Lenting K, Mul AN, Dimitrakopoulou D, van Drunen CM, Hoebe RA, Radivoyevitch T, Wilmink JW, Maciejewski JP, Vandertop WP, Leenders WP, Bleeker FE, van Noorden CJ. Molenaar RJ, et al. Among authors: leenders wp. Cancer Res. 2015 Nov 15;75(22):4790-802. doi: 10.1158/0008-5472.CAN-14-3603. Epub 2015 Sep 11. Cancer Res. 2015. PMID: 26363012
Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.
Navis AC, Niclou SP, Fack F, Stieber D, van Lith S, Verrijp K, Wright A, Stauber J, Tops B, Otte-Holler I, Wevers RA, van Rooij A, Pusch S, von Deimling A, Tigchelaar W, van Noorden CJ, Wesseling P, Leenders WP. Navis AC, et al. Among authors: leenders wp. Acta Neuropathol Commun. 2013 May 29;1:18. doi: 10.1186/2051-5960-1-18. Acta Neuropathol Commun. 2013. PMID: 24252742 Free PMC article.
Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers?
van Lith SA, Navis AC, Verrijp K, Niclou SP, Bjerkvig R, Wesseling P, Tops B, Molenaar R, van Noorden CJ, Leenders WP. van Lith SA, et al. Among authors: leenders wp. Biochim Biophys Acta. 2014 Aug;1846(1):66-74. doi: 10.1016/j.bbcan.2014.04.004. Epub 2014 Apr 18. Biochim Biophys Acta. 2014. PMID: 24747768 Review.
Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein.
Navis AC, van Lith SA, van Duijnhoven SM, de Pooter M, Yetkin-Arik B, Wesseling P, Hendriks WJ, Venselaar H, Timmer M, van Cleef P, van Bergen En Henegouwen P, Best MG, Wurdinger TD, Tops BB, Leenders WP. Navis AC, et al. Among authors: leenders wp. Acta Neuropathol. 2015 Jul;130(1):131-44. doi: 10.1007/s00401-015-1420-5. Epub 2015 Apr 11. Acta Neuropathol. 2015. PMID: 25862637 Free PMC article.
Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.
van Lith SA, Navis AC, Lenting K, Verrijp K, Schepens JT, Hendriks WJ, Schubert NA, Venselaar H, Wevers RA, van Rooij A, Wesseling P, Molenaar RJ, van Noorden CJ, Pusch S, Tops B, Leenders WP. van Lith SA, et al. Among authors: leenders wp. Sci Rep. 2016 Jul 27;6:30486. doi: 10.1038/srep30486. Sci Rep. 2016. PMID: 27460417 Free PMC article.
In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued.
van Lith SA, Roodink I, Verhoeff JJ, Mäkinen PI, Lappalainen JP, Ylä-Herttuala S, Raats J, van Wijk E, Roepman R, Letteboer SJ, Verrijp K, Leenders WP. van Lith SA, et al. Among authors: leenders wp. Oncotarget. 2016 Nov 1;7(44):71594-71607. doi: 10.18632/oncotarget.12261. Oncotarget. 2016. PMID: 27689404 Free PMC article.
Glioma: experimental models and reality.
Lenting K, Verhaak R, Ter Laan M, Wesseling P, Leenders W. Lenting K, et al. Acta Neuropathol. 2017 Feb;133(2):263-282. doi: 10.1007/s00401-017-1671-4. Epub 2017 Jan 10. Acta Neuropathol. 2017. PMID: 28074274 Free PMC article. Review.
120 results