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Simultaneous detection of single molecules and singulated ensembles of molecules enables immunoassays with broad dynamic range.
Rissin DM, Fournier DR, Piech T, Kan CW, Campbell TG, Song L, Chang L, Rivnak AJ, Patel PP, Provuncher GK, Ferrell EP, Howes SC, Pink BA, Minnehan KA, Wilson DH, Duffy DC. Rissin DM, et al. Among authors: chang l. Anal Chem. 2011 Mar 15;83(6):2279-85. doi: 10.1021/ac103161b. Epub 2011 Feb 23. Anal Chem. 2011. PMID: 21344864 Free PMC article.
Single molecule measurements of tumor necrosis factor α and interleukin-6 in the plasma of patients with Crohn's disease.
Song L, Hanlon DW, Chang L, Provuncher GK, Kan CW, Campbell TG, Fournier DR, Ferrell EP, Rivnak AJ, Pink BA, Minnehan KA, Patel PP, Wilson DH, Till MA, Faubion WA, Duffy DC. Song L, et al. Among authors: chang l. J Immunol Methods. 2011 Sep 30;372(1-2):177-86. doi: 10.1016/j.jim.2011.07.015. Epub 2011 Jul 27. J Immunol Methods. 2011. PMID: 21821036
Isolation and detection of single molecules on paramagnetic beads using sequential fluid flows in microfabricated polymer array assemblies.
Kan CW, Rivnak AJ, Campbell TG, Piech T, Rissin DM, Mösl M, Peterça A, Niederberger HP, Minnehan KA, Patel PP, Ferrell EP, Meyer RE, Chang L, Wilson DH, Fournier DR, Duffy DC. Kan CW, et al. Among authors: chang l. Lab Chip. 2012 Mar 7;12(5):977-85. doi: 10.1039/c2lc20744c. Epub 2011 Dec 16. Lab Chip. 2012. PMID: 22179487
The Simoa HD-1 Analyzer: A Novel Fully Automated Digital Immunoassay Analyzer with Single-Molecule Sensitivity and Multiplexing.
Wilson DH, Rissin DM, Kan CW, Fournier DR, Piech T, Campbell TG, Meyer RE, Fishburn MW, Cabrera C, Patel PP, Frew E, Chen Y, Chang L, Ferrell EP, von Einem V, McGuigan W, Reinhardt M, Sayer H, Vielsack C, Duffy DC. Wilson DH, et al. Among authors: chang l. J Lab Autom. 2016 Aug;21(4):533-47. doi: 10.1177/2211068215589580. Epub 2015 Jun 15. J Lab Autom. 2016. PMID: 26077162
N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection.
Shan D, Johnson JM, Fernandes SC, Suib H, Hwang S, Wuelfing D, Mendes M, Holdridge M, Burke EM, Beauregard K, Zhang Y, Cleary M, Xu S, Yao X, Patel PP, Plavina T, Wilson DH, Chang L, Kaiser KM, Nattermann J, Schmidt SV, Latz E, Hrusovsky K, Mattoon D, Ball AJ. Shan D, et al. Among authors: chang l. Nat Commun. 2021 Mar 26;12(1):1931. doi: 10.1038/s41467-021-22072-9. Nat Commun. 2021. PMID: 33771993 Free PMC article.
9,568 results