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Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice.
Miethke AG, Zhang W, Simmons J, Taylor AE, Shi T, Shanmukhappa SK, Karns R, White S, Jegga AG, Lages CS, Nkinin S, Keller BT, Setchell KD. Miethke AG, et al. Among authors: shanmukhappa sk. Hepatology. 2016 Feb;63(2):512-23. doi: 10.1002/hep.27973. Epub 2015 Aug 21. Hepatology. 2016. PMID: 26172874 Free PMC article.
Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology.
Bakeer N, James J, Roy S, Wansapura J, Shanmukhappa SK, Lorenz JN, Osinska H, Backer K, Huby AC, Shrestha A, Niss O, Fleck R, Quinn CT, Taylor MD, Purevjav E, Aronow BJ, Towbin JA, Malik P. Bakeer N, et al. Among authors: shanmukhappa sk. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5182-91. doi: 10.1073/pnas.1600311113. Epub 2016 Aug 8. Proc Natl Acad Sci U S A. 2016. PMID: 27503873 Free PMC article.
Obesity enhances sepsis-induced liver inflammation and injury in mice.
Kaplan JM, Nowell M, Lahni P, Shen H, Shanmukhappa SK, Zingarelli B. Kaplan JM, et al. Among authors: shanmukhappa sk. Obesity (Silver Spring). 2016 Jul;24(7):1480-8. doi: 10.1002/oby.21504. Epub 2016 May 13. Obesity (Silver Spring). 2016. PMID: 27172993 Free PMC article.
Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.
Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S. Giles DA, et al. Among authors: shanmukhappa sk. Nat Med. 2017 Jul;23(7):829-838. doi: 10.1038/nm.4346. Epub 2017 Jun 12. Nat Med. 2017. PMID: 28604704 Free PMC article.
24 results