Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies.
Vingtdeux V, Hamdane M, Loyens A, Gelé P, Drobeck H, Bégard S, Galas MC, Delacourte A, Beauvillain JC, Buée L, Sergeant N.
Vingtdeux V, et al. Among authors: buee l.
J Biol Chem. 2007 Jun 22;282(25):18197-18205. doi: 10.1074/jbc.M609475200. Epub 2007 Apr 27.
J Biol Chem. 2007.
PMID: 17468104
Free article.
We showed recently that the amyloid intracellular domain (AICD), which is released by gamma-secretase cleavage of APP C-terminal fragments (CTFs), is strongly increased in cells treated with alkalizing drugs (Vingtdeux, V., Hamdane, M., Begard, S., Loyens, A., Delacourte, A., Bea …
We showed recently that the amyloid intracellular domain (AICD), which is released by gamma-secretase cleavage of APP C-terminal fragments ( …