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A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity.
Tian H, Shi G, Wang Q, Li Y, Yang Q, Li C, Yang G, Wu M, Xie Q, Zhang S, Yang Y, Xiang R, Yu D, Wei Y, Deng H. Tian H, et al. Among authors: zhang s. Signal Transduct Target Ther. 2016 Nov 18;1:16025. doi: 10.1038/sigtrans.2016.25. eCollection 2016. Signal Transduct Target Ther. 2016. PMID: 29263903 Free PMC article.
Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.
Tian H, Shi G, Yang G, Zhang J, Li Y, Du T, Wang J, Xu F, Cheng L, Zhang X, Dai L, Chen X, Zhang S, Yang Y, Yu D, Wei Y, Deng H. Tian H, et al. Among authors: zhang s, zhang j, zhang x. BMC Cancer. 2014 Jan 29;14:48. doi: 10.1186/1471-2407-14-48. BMC Cancer. 2014. Retraction in: BMC Cancer. 2023 Jul 3;23(1):612. doi: 10.1186/s12885-023-11123-7 PMID: 24475975 Free PMC article. Retracted.
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