Locke C - Search Results

1

Clinical safety and hypothalamic-pituitary-adrenal axis effects of the arginine vasopressin type 1B receptor antagonist ABT-436.

Katz DA, Liu W, Locke C, Dutta S, Tracy KA. Katz DA, et al. Among authors: locke c. Psychopharmacology (Berl). 2016 Jan;233(1):71-81. doi: 10.1007/s00213-015-4089-5. Epub 2015 Sep 26. Psychopharmacology (Berl). 2016. PMID: 26407603 Clinical Trial.

2

Single-Dose Interaction Study of the Arginine Vasopressin Type 1B Receptor Antagonist ABT-436 and Alcohol in Moderate Alcohol Drinkers.

Katz DA, Locke C, Liu W, Zhang J, Achari R, Wesnes KA, Tracy KA. Katz DA, et al. Among authors: locke c. Alcohol Clin Exp Res. 2016 Apr;40(4):838-45. doi: 10.1111/acer.12996. Epub 2016 Mar 10. Alcohol Clin Exp Res. 2016. PMID: 26969417 Clinical Trial.

3

Hypothalamic-pituitary-adrenal axis and depression symptom effects of an arginine vasopressin type 1B receptor antagonist in a one-week randomized Phase 1b trial.

Katz DA, Locke C, Greco N, Liu W, Tracy KA. Katz DA, et al. Among authors: locke c. Brain Behav. 2017 Feb 9;7(3):e00628. doi: 10.1002/brb3.628. eCollection 2017 Mar. Brain Behav. 2017. PMID: 28293470 Free PMC article. Clinical Trial.

4

Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384.

Katz DA, Liu W, Locke C, Jacobson P, Barnes DM, Basu R, An G, Rieser MJ, Daszkowski D, Groves F, Heneghan G, Shah A, Gevorkyan H, Jhee SS, Ereshefsky L, Marek GJ. Katz DA, et al. Among authors: locke c. Transl Psychiatry. 2013 Aug 27;3(8):e295. doi: 10.1038/tp.2013.67. Transl Psychiatry. 2013. PMID: 23982627 Free PMC article. Clinical Trial.

5

Safety, tolerability and pharmacokinetics of the histamine H3 receptor antagonist, ABT-288, in healthy young adults and elderly volunteers.

Othman AA, Haig G, Florian H, Locke C, Zhang J, Dutta S. Othman AA, et al. Among authors: locke c. Br J Clin Pharmacol. 2013 May;75(5):1299-311. doi: 10.1111/j.1365-2125.2012.04472.x. Br J Clin Pharmacol. 2013. PMID: 23016924 Free PMC article. Clinical Trial.

6

The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers.

Othman AA, Haig G, Florian H, Locke C, Gertsik L, Dutta S. Othman AA, et al. Among authors: locke c. Br J Clin Pharmacol. 2014 Jun;77(6):965-74. doi: 10.1111/bcp.12281. Br J Clin Pharmacol. 2014. PMID: 24215171 Free PMC article. Clinical Trial.

7

Clinical Safety, Pharmacokinetics, and Pharmacodynamics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers and Elderly Adults.

Liu W, Katz DA, Locke C, Daszkowski D, Wang Y, Rieser MJ, Awni W, Marek GJ, Dutta S. Liu W, et al. Among authors: locke c. Clin Pharmacol Drug Dev. 2013 Apr;2(2):133-51. doi: 10.1002/cpdd.5. Epub 2013 Feb 21. Clin Pharmacol Drug Dev. 2013. PMID: 27121668

8

A Randomized, Double-Blind, Placebo-Controlled, Crossover Study of the T-Type Calcium Channel Blocker ABT-639 in an Intradermal Capsaicin Experimental Pain Model in Healthy Adults.

Wallace M, Duan R, Liu W, Locke C, Nothaft W. Wallace M, et al. Among authors: locke c. Pain Med. 2016 Mar;17(3):551-560. doi: 10.1093/pm/pnv068. Epub 2015 Dec 16. Pain Med. 2016. PMID: 26814294 Clinical Trial.

9

Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial.

Serra J, Duan WR, Locke C, Solà R, Liu W, Nothaft W. Serra J, et al. Among authors: locke c. Pain. 2015 Nov;156(11):2175-2183. doi: 10.1097/j.pain.0000000000000249. Pain. 2015. PMID: 26035253 Clinical Trial.

10

Levodopa-Carbidopa Intestinal Gel Pharmacokinetics: Lower Variability than Oral Levodopa-Carbidopa.

Othman AA, Rosebraugh M, Chatamra K, Locke C, Dutta S. Othman AA, et al. Among authors: locke c. J Parkinsons Dis. 2017;7(2):275-278. doi: 10.3233/JPD-161042. J Parkinsons Dis. 2017. PMID: 28211816 Free PMC article. Clinical Trial.

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