Magee M - Search Results

1

Single and Multiple Dose Pharmacokinetics, Pharmacodynamics and Safety of the Novel Lipoprotein-Associated Phospholipase A2 Enzyme Inhibitor Darapladib in Healthy Chinese Subjects: An Open Label Phase-1 Clinical Trial.

Hu C, Tompson D, Magee M, Chen Q, Liu YM, Zhu W, Zhao H, Gross AS, Liu Y. Hu C, et al. Among authors: magee m. PLoS One. 2015 Oct 14;10(10):e0139862. doi: 10.1371/journal.pone.0139862. eCollection 2015. PLoS One. 2015. PMID: 26465780 Free PMC article. Clinical Trial.

2

Effects of rifampicin (rifampin) on the pharmacokinetics and safety of ambrisentan in healthy subjects: a single-sequence, open-label study.

Harrison B, Magee MH, Mandagere A, Walker G, Dufton C, Henderson LS, Boinpally R. Harrison B, et al. Clin Drug Investig. 2010;30(12):875-885. doi: 10.2165/11539110-000000000-00000. Clin Drug Investig. 2010. PMID: 20923245 Clinical Trial.

3

Disposition and metabolism of darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in humans.

Dave M, Nash M, Young GC, Ellens H, Magee MH, Roberts AD, Taylor MA, Greenhill RW, Boyle GW. Dave M, et al. Among authors: magee mh. Drug Metab Dispos. 2014 Mar;42(3):415-30. doi: 10.1124/dmd.113.054486. Epub 2013 Dec 30. Drug Metab Dispos. 2014. PMID: 24378325 Clinical Trial.

4

Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials.

Shaddinger BC, Xu Y, Roger JH, Macphee CH, Handel M, Baidoo CA, Magee M, Lepore JJ, Sprecher DL. Shaddinger BC, et al. Among authors: magee m. PLoS One. 2014 Jan 27;9(1):e83094. doi: 10.1371/journal.pone.0083094. eCollection 2014. PLoS One. 2014. PMID: 24475026 Free PMC article. Clinical Trial.

5

An effect of moderate hepatic impairment on the pharmacokinetics and safety of darapladib.

Magee MH, Shearn S, Shaddinger B, Fang Z, Glaser R. Magee MH, et al. Br J Clin Pharmacol. 2014 Nov;78(5):1014-21. doi: 10.1111/bcp.12436. Br J Clin Pharmacol. 2014. PMID: 24938621 Free PMC article. Clinical Trial.

6

Darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in diabetic macular edema: a 3-month placebo-controlled study.

Staurenghi G, Ye L, Magee MH, Danis RP, Wurzelmann J, Adamson P, McLaughlin MM; Darapladib DME Study Group. Staurenghi G, et al. Among authors: magee mh. Ophthalmology. 2015 May;122(5):990-6. doi: 10.1016/j.ophtha.2014.12.014. Epub 2015 Mar 5. Ophthalmology. 2015. PMID: 25749297 Clinical Trial.

7

The pharmacokinetics and safety of darapladib in subjects with severe renal impairment.

Magee MH, Shaddinger B, Collins D, Siddiqi S, Soffer J. Magee MH, et al. Br J Clin Pharmacol. 2015 Oct;80(4):654-61. doi: 10.1111/bcp.12661. Epub 2015 Jul 6. Br J Clin Pharmacol. 2015. PMID: 25953363 Free PMC article. Clinical Trial.

8

A Phase 1 Randomized, Placebo-Controlled Study Assessing the Pharmacokinetics, Safety, and Tolerability of Retosiban in Healthy, Nonpregnant Japanese Subjects.

Caltabiano S, Magee MH, Liu F, Beach KJ. Caltabiano S, et al. Clin Pharmacol Drug Dev. 2018 Jan;7(1):59-66. doi: 10.1002/cpdd.355. Epub 2017 Apr 17. Clin Pharmacol Drug Dev. 2018. PMID: 28419732 Clinical Trial.

9

Effects of multiple doses of ambrisentan on the pharmacokinetics of a single dose of digoxin in healthy volunteers.

Richards DB, Spence R, Mandagere A, Henderson LS, Magee MH. Richards DB, et al. J Clin Pharmacol. 2011 Jan;51(1):102-6. doi: 10.1177/0091270010362693. Epub 2010 Mar 29. J Clin Pharmacol. 2011. PMID: 20350954 Clinical Trial. No abstract available.

10

Utility of concentration-effect modeling and simulation in a thorough QT study of losmapimod.

Barbour AM, Magee M, Shaddinger B, Arya N, Tombs L, Tao W, Patel BR, Fossler MJ, Glaser R. Barbour AM, et al. Among authors: magee m. J Clin Pharmacol. 2015 Jun;55(6):661-70. doi: 10.1002/jcph.465. Epub 2015 Feb 13. J Clin Pharmacol. 2015. PMID: 25612153 Clinical Trial.

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