Keller TH - Search Results

1

Characterization of the interaction between Escherichia coli topoisomerase IV E subunit and an ATP competitive inhibitor.

Li Y, Wong YL, Ng FM, Liu B, Wong YX, Poh ZY, Then SW, Lee MY, Ng HQ, Hung AW, Cherian J, Hill J, Keller TH, Kang C. Li Y, et al. Among authors: keller th. Biochem Biophys Res Commun. 2015 Nov 27;467(4):961-6. doi: 10.1016/j.bbrc.2015.10.036. Epub 2015 Oct 17. Biochem Biophys Res Commun. 2015. PMID: 26471301

2

NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor.

Li Y, Wong YX, Poh ZY, Wong YL, Lee MY, Ng HQ, Liu B, Hung AW, Cherian J, Hill J, Keller TH, Kang C. Li Y, et al. Among authors: keller th. FEBS Lett. 2015 Sep 14;589(19 Pt B):2683-9. doi: 10.1016/j.febslet.2015.07.044. Epub 2015 Aug 10. FEBS Lett. 2015. PMID: 26272827 Free article.

3

Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an Inhibitor.

Kang C, Li Y, Cherian J, Liu B, Ng HQ, Lee MY, Binte Ahmad NH, Poh ZY, Wong YX, Huang Q, Wong YL, Hung AW, Hill J, Keller TH. Kang C, et al. Among authors: keller th. Biophys J. 2015 Nov 3;109(9):1969-77. doi: 10.1016/j.bpj.2015.10.001. Biophys J. 2015. PMID: 26536273 Free PMC article.

4

Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy.

Li Y, Wong YL, Ng FM, Liu B, Wong YX, Poh ZY, Liu S, Then SW, Lee MY, Ng HQ, Huang Q, Hung AW, Cherian J, Hill J, Keller TH, Kang C. Li Y, et al. Among authors: keller th. J Biol Chem. 2016 Aug 19;291(34):17743-53. doi: 10.1074/jbc.M116.737429. Epub 2016 Jun 30. J Biol Chem. 2016. PMID: 27365392 Free PMC article.

5

Structural and ligand-binding analysis of the YAP-binding domain of transcription factor TEAD4.

Li Y, Liu S, Ng EY, Li R, Poulsen A, Hill J, Pobbati AV, Hung AW, Hong W, Keller TH, Kang C. Li Y, et al. Among authors: keller th. Biochem J. 2018 Jun 26;475(12):2043-2055. doi: 10.1042/BCJ20180225. Biochem J. 2018. PMID: 29760238

6

Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria.

Ho SY, Wang W, Ng FM, Wong YX, Poh ZY, Tan SWE, Ang SH, Liew SS, Joyner Wong YS, Tan Y, Poulsen A, Pendharkar V, Sangthongpitag K, Manchester J, Basarab G, Hill J, Keller TH, Cherian J. Ho SY, et al. Among authors: keller th. Eur J Med Chem. 2018 Sep 5;157:610-621. doi: 10.1016/j.ejmech.2018.08.025. Epub 2018 Aug 11. Eur J Med Chem. 2018. PMID: 30125722

7

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex.

Kim YM, Gayen S, Kang C, Joy J, Huang Q, Chen AS, Wee JL, Ang MJ, Lim HA, Hung AW, Li R, Noble CG, Lee le T, Yip A, Wang QY, Chia CS, Hill J, Shi PY, Keller TH. Kim YM, et al. Among authors: keller th. J Biol Chem. 2013 May 3;288(18):12891-900. doi: 10.1074/jbc.M112.442723. Epub 2013 Mar 19. J Biol Chem. 2013. PMID: 23511634 Free PMC article.

8

Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study.

Ang MJ, Lau QY, Ng FM, Then SW, Poulsen A, Cheong YK, Ngoh ZX, Tan YW, Peng J, Keller TH, Hill J, Chu JJ, Chia CS. Ang MJ, et al. Among authors: keller th. J Enzyme Inhib Med Chem. 2016;31(2):332-9. doi: 10.3109/14756366.2015.1018245. Epub 2015 Sep 4. J Enzyme Inhib Med Chem. 2016. PMID: 25792507

9

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors.

Li Y, Zhang Z, Phoo WW, Loh YR, Wang W, Liu S, Chen MW, Hung AW, Keller TH, Luo D, Kang C. Li Y, et al. Among authors: keller th. Structure. 2017 Aug 1;25(8):1242-1250.e3. doi: 10.1016/j.str.2017.06.006. Epub 2017 Jul 6. Structure. 2017. PMID: 28689970 Free article.

10

Zika Virus Protease: An Antiviral Drug Target.

Kang C, Keller TH, Luo D. Kang C, et al. Among authors: keller th. Trends Microbiol. 2017 Oct;25(10):797-808. doi: 10.1016/j.tim.2017.07.001. Epub 2017 Aug 5. Trends Microbiol. 2017. PMID: 28789826 Review.

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