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Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia.
Luo J, Lee SH, VandeVrede L, Qin Z, Piyankarage S, Tavassoli E, Asghodom RT, Ben Aissa M, Fà M, Arancio O, Yue L, Pepperberg DR, Thatcher GR. Luo J, et al. Among authors: ben aissa m. BMC Neurosci. 2015 Oct 19;16:67. doi: 10.1186/s12868-015-0208-9. BMC Neurosci. 2015. PMID: 26480871 Free PMC article.
A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease.
Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. Luo J, et al. Among authors: ben aissa m. Mol Neurodegener. 2016 Apr 29;11:35. doi: 10.1186/s13024-016-0103-6. Mol Neurodegener. 2016. PMID: 27129593 Free PMC article.
Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery.
Hollas MA, Ben Aissa M, Lee SH, Gordon-Blake JM, Thatcher GRJ. Hollas MA, et al. Among authors: ben aissa m. Nitric Oxide. 2019 Jan 1;82:59-74. doi: 10.1016/j.niox.2018.10.006. Epub 2018 Oct 28. Nitric Oxide. 2019. PMID: 30394348 Free PMC article. Review.
Soluble guanylyl cyclase is a critical regulator of migraine-associated pain.
Ben Aissa M, Tipton AF, Bertels Z, Gandhi R, Moye LS, Novack M, Bennett BM, Wang Y, Litosh V, Lee SH, Gaisina IN, Thatcher GR, Pradhan AA. Ben Aissa M, et al. Cephalalgia. 2018 Jul;38(8):1471-1484. doi: 10.1177/0333102417737778. Epub 2017 Oct 12. Cephalalgia. 2018. PMID: 29022756 Free PMC article.
Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors.
Gaisina IN, Lee SH, Kaidery NA, Ben Aissa M, Ahuja M, Smirnova NN, Wakade S, Gaisin A, Bourassa MW, Ratan RR, Nikulin SV, Poloznikov AA, Thomas B, Thatcher GRJ, Gazaryan IG. Gaisina IN, et al. Among authors: ben aissa m. ACS Chem Neurosci. 2018 May 16;9(5):894-900. doi: 10.1021/acschemneuro.7b00435. Epub 2018 Jan 17. ACS Chem Neurosci. 2018. PMID: 29338172 Free PMC article.
39 results