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The T4bSS of Legionella features a two-step secretion pathway with an inner membrane intermediate for secretion of transmembrane effectors.
Malmsheimer S, Grin I, Bohn E, Franz-Wachtel M, Macek B, Sahr T, Smollich F, Chetrit D, Meir A, Roy C, Buchrieser C, Wagner S. Malmsheimer S, et al. bioRxiv [Preprint]. 2024 Mar 14:2024.03.14.584949. doi: 10.1101/2024.03.14.584949. bioRxiv. 2024. Update in: PLoS Pathog. 2024 Nov 15;20(11):e1012118. doi: 10.1371/journal.ppat.1012118. PMID: 38559167 Free PMC article. Updated. Preprint.
Therapeutically useful mycobacteriophages BPs and Muddy require trehalose polyphleates.
Wetzel KS, Illouz M, Abad L, Aull HG, Russell DA, Garlena RA, Cristinziano M, Malmsheimer S, Chalut C, Hatfull GF, Kremer L. Wetzel KS, et al. Among authors: malmsheimer s. Nat Microbiol. 2023 Sep;8(9):1717-1731. doi: 10.1038/s41564-023-01451-6. Epub 2023 Aug 24. Nat Microbiol. 2023. PMID: 37644325 Free PMC article.
Mycobacterium trehalose polyphleates are required for infection by therapeutically useful mycobacteriophages BPs and Muddy.
Wetzel KS, Illouz M, Abad L, Aull HG, Russell DA, Garlena RA, Cristinziano M, Malmsheimer S, Chalut C, Hatfull GF, Kremer L. Wetzel KS, et al. Among authors: malmsheimer s. bioRxiv [Preprint]. 2023 Jun 3:2023.03.14.532567. doi: 10.1101/2023.03.14.532567. bioRxiv. 2023. Update in: Nat Microbiol. 2023 Sep;8(9):1717-1731. doi: 10.1038/s41564-023-01451-6. PMID: 36993724 Free PMC article. Updated. Preprint.
Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones.
Herbel SM, Moyon L, Christ M, Elsayed EM, Caffrey BE, Malmsheimer S, Grin I, Hoffmann K, Surmann K, Blankenburg S, Jung AL, Herkt CE, Borsò M, Bozdag B, Imhof A, Becker A, Wagner S, Bange G, Völker U, Bertrams W, Marsico A, Schmeck B. Herbel SM, et al. Among authors: malmsheimer s. Virulence. 2022 Dec;13(1):2042-2058. doi: 10.1080/21505594.2022.2149973. Virulence. 2022. PMID: 36411449 Free PMC article.
Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease.
Jesse S, Bayer H, Alupei MC, Zügel M, Mulaw M, Tuorto F, Malmsheimer S, Singh K, Steinacker J, Schumann U, Ludolph AC, Scharffetter-Kochanek K, Witting A, Weydt P, Iben S. Jesse S, et al. Among authors: malmsheimer s. Sci Rep. 2017 Aug 17;7(1):8513. doi: 10.1038/s41598-017-09148-7. Sci Rep. 2017. PMID: 28819135 Free PMC article.
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