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Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses.
Honke N, Shaabani N, Merches K, Gassa A, Kraft A, Ehrhardt K, Häussinger D, Löhning M, Dittmer U, Hengel H, Recher M, Lang PA, Lang KS. Honke N, et al. Among authors: lohning m. Eur J Immunol. 2016 Feb;46(2):372-80. doi: 10.1002/eji.201545765. Epub 2015 Nov 17. Eur J Immunol. 2016. PMID: 26507703 Free PMC article.
Aggravation of viral hepatitis by platelet-derived serotonin.
Lang PA, Contaldo C, Georgiev P, El-Badry AM, Recher M, Kurrer M, Cervantes-Barragan L, Ludewig B, Calzascia T, Bolinger B, Merkler D, Odermatt B, Bader M, Graf R, Clavien PA, Hegazy AN, Löhning M, Harris NL, Ohashi PS, Hengartner H, Zinkernagel RM, Lang KS. Lang PA, et al. Among authors: lohning m. Nat Med. 2008 Jul;14(7):756-61. doi: 10.1038/nm1780. Epub 2008 May 30. Nat Med. 2008. PMID: 18516052 Free article.
Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus.
Honke N, Shaabani N, Cadeddu G, Sorg UR, Zhang DE, Trilling M, Klingel K, Sauter M, Kandolf R, Gailus N, van Rooijen N, Burkart C, Baldus SE, Grusdat M, Löhning M, Hengel H, Pfeffer K, Tanaka M, Häussinger D, Recher M, Lang PA, Lang KS. Honke N, et al. Among authors: lohning m. Nat Immunol. 2011 Nov 20;13(1):51-7. doi: 10.1038/ni.2169. Nat Immunol. 2011. PMID: 22101728
Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.
Xu HC, Grusdat M, Pandyra AA, Polz R, Huang J, Sharma P, Deenen R, Köhrer K, Rahbar R, Diefenbach A, Gibbert K, Löhning M, Höcker L, Waibler Z, Häussinger D, Mak TW, Ohashi PS, Lang KS, Lang PA. Xu HC, et al. Among authors: lohning m. Immunity. 2014 Jun 19;40(6):949-60. doi: 10.1016/j.immuni.2014.05.004. Epub 2014 Jun 5. Immunity. 2014. PMID: 24909887 Free article.
Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection.
Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häussinger D, Recher M, Lang KS, Lang PA. Xu HC, et al. Among authors: lohning m. J Virol. 2015 May;89(9):4748-59. doi: 10.1128/JVI.02976-14. Epub 2015 Feb 11. J Virol. 2015. PMID: 25673724 Free PMC article.
Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage.
Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A. Bhattacharya A, et al. Among authors: lohning m. Immunity. 2015 Nov 17;43(5):974-86. doi: 10.1016/j.immuni.2015.10.013. Immunity. 2015. PMID: 26588782 Free PMC article.
85 results