Castro RA - Search Results

1

The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers.

Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM. Morrissey KM, et al. Among authors: castro ra. Clin Pharmacokinet. 2016 Apr;55(4):495-506. doi: 10.1007/s40262-015-0332-9. Clin Pharmacokinet. 2016. PMID: 26507723 Free PMC article.

2

Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.

Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM. Goswami S, et al. Clin Pharmacol Ther. 2014 Sep;96(3):370-9. doi: 10.1038/clpt.2014.109. Epub 2014 May 22. Clin Pharmacol Ther. 2014. PMID: 24853734 Free PMC article.

3

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.

Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM. Shu Y, et al. Among authors: castro ra. Clin Pharmacol Ther. 2008 Feb;83(2):273-80. doi: 10.1038/sj.clpt.6100275. Epub 2007 Jul 4. Clin Pharmacol Ther. 2008. PMID: 17609683 Free PMC article. Clinical Trial.

4

The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.

Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM. Stocker SL, et al. Among authors: castro ra. Clin Pharmacol Ther. 2013 Feb;93(2):186-94. doi: 10.1038/clpt.2012.210. Epub 2012 Oct 17. Clin Pharmacol Ther. 2013. PMID: 23267855 Free PMC article.

5

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.

Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM. Shu Y, et al. Among authors: castro ra. J Clin Invest. 2007 May;117(5):1422-31. doi: 10.1172/JCI30558. J Clin Invest. 2007. PMID: 17476361 Free PMC article.

6

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.

Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM. Chen Y, et al. Among authors: castro ra. Pharmacogenet Genomics. 2009 Jul;19(7):497-504. doi: 10.1097/FPC.0b013e32832cc7e9. Pharmacogenet Genomics. 2009. PMID: 19483665 Free PMC article. Clinical Trial.

7

Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8).

Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM. Yee SW, et al. Among authors: castro ra. J Pharm Sci. 2013 Sep;102(9):3451-7. doi: 10.1002/jps.23581. Epub 2013 May 6. J Pharm Sci. 2013. PMID: 23649425 Free PMC article.

8

The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.

Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM. Hibma JE, et al. Among authors: castro ra. Clin Pharmacokinet. 2016 Jun;55(6):711-21. doi: 10.1007/s40262-015-0346-3. Clin Pharmacokinet. 2016. PMID: 26597253 Free PMC article. Clinical Trial.

9

Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin.

Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM. Urban TJ, et al. Among authors: castro ra. Clin Pharmacol Ther. 2008 Mar;83(3):416-21. doi: 10.1038/sj.clpt.6100271. Epub 2007 Jul 4. Clin Pharmacol Ther. 2008. PMID: 17609685

10

A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.

Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM. Choi JH, et al. Among authors: castro ra. Clin Pharmacol Ther. 2011 Nov;90(5):674-84. doi: 10.1038/clpt.2011.165. Epub 2011 Sep 28. Clin Pharmacol Ther. 2011. PMID: 21956618 Free PMC article.

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