Brockmeier U - Search Results

1

Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics.

Hussmann M, Janke K, Kranz P, Neumann F, Mersch E, Baumann M, Goepelt K, Brockmeier U, Metzen E. Hussmann M, et al. Among authors: brockmeier u. Oncotarget. 2015 Nov 17;6(36):39247-61. doi: 10.18632/oncotarget.5746. Oncotarget. 2015. PMID: 26513173 Free PMC article.

2

PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR).

Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U. Kranz P, et al. Among authors: brockmeier u. Cell Death Dis. 2017 Aug 10;8(8):e2986. doi: 10.1038/cddis.2017.369. Cell Death Dis. 2017. PMID: 28796255 Free PMC article.

3

Autophagy induced by ionizing radiation promotes cell death over survival in human colorectal cancer cells.

Classen F, Kranz P, Riffkin H, Pompsch M, Wolf A, Göpelt K, Baumann M, Baumann J, Brockmeier U, Metzen E. Classen F, et al. Among authors: brockmeier u. Exp Cell Res. 2019 Jan 1;374(1):29-37. doi: 10.1016/j.yexcr.2018.11.004. Epub 2018 Nov 6. Exp Cell Res. 2019. PMID: 30412717 Free article.

4

Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress.

Kranz P, Sänger C, Wolf A, Baumann J, Metzen E, Baumann M, Göpelt K, Brockmeier U. Kranz P, et al. Among authors: brockmeier u. Sci Rep. 2020 Sep 17;10(1):15299. doi: 10.1038/s41598-020-72259-1. Sci Rep. 2020. PMID: 32943707 Free PMC article.

5

In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway.

Ocklenburg T, Neumann F, Wolf A, Vogel J, Göpelt K, Baumann M, Baumann J, Kranz P, Metzen E, Brockmeier U. Ocklenburg T, et al. Among authors: brockmeier u. Sci Rep. 2021 Mar 30;11(1):7199. doi: 10.1038/s41598-021-86658-5. Sci Rep. 2021. PMID: 33785835 Free PMC article.

6

Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2).

Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbäurl H, Metzen E. Janke K, et al. Among authors: brockmeier u. J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40. doi: 10.1242/jcs.117564. Epub 2013 Apr 19. J Cell Sci. 2013. PMID: 23606740

7

The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia.

Pompsch M, Vogel J, Classen F, Kranz P, Iliakis G, Riffkin H, Brockmeier U, Metzen E. Pompsch M, et al. Among authors: brockmeier u. BMC Cancer. 2018 Nov 29;18(1):1190. doi: 10.1186/s12885-018-5095-x. BMC Cancer. 2018. PMID: 30497423 Free PMC article.

8

Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis.

Küper A, Baumann J, Göpelt K, Baumann M, Sänger C, Metzen E, Kranz P, Brockmeier U. Küper A, et al. Among authors: brockmeier u. Cell Death Dis. 2021 Jan 13;12(1):82. doi: 10.1038/s41419-020-03319-7. Cell Death Dis. 2021. PMID: 33441543 Free PMC article.

9

Dissecting VHL-associated pathologies.

Metzen E, Brockmeier U. Metzen E, et al. Among authors: brockmeier u. Blood. 2009 Jun 18;113(25):6273-4. doi: 10.1182/blood-2009-04-214304. Blood. 2009. PMID: 19541835 Free article. No abstract available.

10

The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9.

Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E. Brockmeier U, et al. PLoS One. 2011 Apr 29;6(4):e19151. doi: 10.1371/journal.pone.0019151. PLoS One. 2011. PMID: 21559462 Free PMC article.

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