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Page 1
Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling.
Brandolini L, Cristiano L, Fidoamore A, De Pizzol M, Di Giacomo E, Florio TM, Confalone G, Galante A, Cinque B, Benedetti E, Ruffini PA, Cifone MG, Giordano A, Alecci M, Allegretti M, Cimini A. Brandolini L, et al. Among authors: allegretti m. Oncotarget. 2015 Dec 22;6(41):43375-94. doi: 10.18632/oncotarget.6234. Oncotarget. 2015. PMID: 26517518 Free PMC article.
Relevance of Spike/Estrogen Receptor-α interaction for endothelial-based coagulopathy induced by SARS-CoV-2.
Barbieri SS, Cattani F, Sandrini L, Grillo MM, Amendola A, Valente C, Talarico C, Iaconis D, Turacchio G, Lucariello M, Lione L, Salvatori E, Amadio P, Garoffolo G, Maffei M, Galli F, Beccari AR, Sberna G, Marra E, Zoppi M, Michaelides M, Roscilli G, Aurisicchio L, Bertini R, Allegretti M, Pesce M. Barbieri SS, et al. Among authors: allegretti m. Signal Transduct Target Ther. 2023 May 19;8(1):203. doi: 10.1038/s41392-023-01488-3. Signal Transduct Target Ther. 2023. PMID: 37208343 Free PMC article. No abstract available.
Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.
Bertini R, Allegretti M, Bizzarri C, Moriconi A, Locati M, Zampella G, Cervellera MN, Di Cioccio V, Cesta MC, Galliera E, Martinez FO, Di Bitondo R, Troiani G, Sabbatini V, D'Anniballe G, Anacardio R, Cutrin JC, Cavalieri B, Mainiero F, Strippoli R, Villa P, Di Girolamo M, Martin F, Gentile M, Santoni A, Corda D, Poli G, Mantovani A, Ghezzi P, Colotta F. Bertini R, et al. Among authors: allegretti m. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6. doi: 10.1073/pnas.0402090101. Epub 2004 Jul 28. Proc Natl Acad Sci U S A. 2004. PMID: 15282370 Free PMC article.
CXCR1/2 inhibition enhances pancreatic islet survival after transplantation.
Citro A, Cantarelli E, Maffi P, Nano R, Melzi R, Mercalli A, Dugnani E, Sordi V, Magistretti P, Daffonchio L, Ruffini PA, Allegretti M, Secchi A, Bonifacio E, Piemonti L. Citro A, et al. Among authors: allegretti m. J Clin Invest. 2012 Oct;122(10):3647-51. doi: 10.1172/JCI63089. Epub 2012 Sep 17. J Clin Invest. 2012. PMID: 22996693 Free PMC article. Clinical Trial.
CXCR1/2 inhibition blocks and reverses type 1 diabetes in mice.
Citro A, Valle A, Cantarelli E, Mercalli A, Pellegrini S, Liberati D, Daffonchio L, Kastsiuchenka O, Ruffini PA, Battaglia M, Allegretti M, Piemonti L. Citro A, et al. Among authors: allegretti m. Diabetes. 2015 Apr;64(4):1329-40. doi: 10.2337/db14-0443. Epub 2014 Oct 14. Diabetes. 2015. PMID: 25315007
Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief.
Moriconi A, Cunha TM, Souza GR, Lopes AH, Cunha FQ, Carneiro VL, Pinto LG, Brandolini L, Aramini A, Bizzarri C, Bianchini G, Beccari AR, Fanton M, Bruno A, Costantino G, Bertini R, Galliera E, Locati M, Ferreira SH, Teixeira MM, Allegretti M. Moriconi A, et al. Among authors: allegretti m. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16937-42. doi: 10.1073/pnas.1417365111. Epub 2014 Nov 10. Proc Natl Acad Sci U S A. 2014. PMID: 25385614 Free PMC article.
DFL23448, A Novel Transient Receptor Potential Melastin 8-Selective Ion Channel Antagonist, Modifies Bladder Function and Reduces Bladder Overactivity in Awake Rats.
Mistretta FA, Russo A, Castiglione F, Bettiga A, Colciago G, Montorsi F, Brandolini L, Aramini A, Bianchini G, Allegretti M, Bovolenta S, Russo R, Benigni F, Hedlund P. Mistretta FA, et al. Among authors: allegretti m. J Pharmacol Exp Ther. 2016 Jan;356(1):200-11. doi: 10.1124/jpet.115.228684. Epub 2015 Nov 6. J Pharmacol Exp Ther. 2016. PMID: 26546575
173 results