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OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. Chen L, et al. Among authors: chien hc. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8. doi: 10.1073/pnas.1314939111. Epub 2014 Jun 24. Proc Natl Acad Sci U S A. 2014. PMID: 24961373 Free PMC article.
Prediction and validation of enzyme and transporter off-targets for metformin.
Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM. Yee SW, et al. Among authors: chien hc. J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):463-75. doi: 10.1007/s10928-015-9436-y. Epub 2015 Sep 3. J Pharmacokinet Pharmacodyn. 2015. PMID: 26335661 Free PMC article.
LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs.
Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. Augustyn E, et al. Among authors: chien hc. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2616-2621. doi: 10.1016/j.bmcl.2016.04.023. Epub 2016 Apr 11. Bioorg Med Chem Lett. 2016. PMID: 27106710 Free PMC article.
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L; MetGen Investigators; DPP Investigators; ACCORD Investigators; Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER. Zhou K, et al. Among authors: chien hc. Nat Genet. 2016 Sep;48(9):1055-1059. doi: 10.1038/ng.3632. Epub 2016 Aug 8. Nat Genet. 2016. PMID: 27500523 Free PMC article.
LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates.
Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K, Hernandez C, Hansen L, Miller S, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. Zur AA, et al. Among authors: chien hc. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5000-5006. doi: 10.1016/j.bmcl.2016.09.001. Epub 2016 Sep 3. Bioorg Med Chem Lett. 2016. PMID: 27624080 Free PMC article.
127 results