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Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
Papillon JP, Lou C, Singh AK, Adams CM, Ksander GM, Beil ME, Chen W, Leung-Chu J, Fu F, Gan L, Hu CW, Jeng AY, LaSala D, Liang G, Rigel DF, Russell KS, Vest JA, Watson C. Papillon JP, et al. Among authors: lou c. J Med Chem. 2015 Dec 10;58(23):9382-94. doi: 10.1021/acs.jmedchem.5b01545. Epub 2015 Nov 18. J Med Chem. 2015. PMID: 26540564
Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.
Papillon JP, Adams CM, Hu QY, Lou C, Singh AK, Zhang C, Carvalho J, Rajan S, Amaral A, Beil ME, Fu F, Gangl E, Hu CW, Jeng AY, LaSala D, Liang G, Logman M, Maniara WM, Rigel DF, Smith SA, Ksander GM. Papillon JP, et al. Among authors: lou c. J Med Chem. 2015 Jun 11;58(11):4749-70. doi: 10.1021/acs.jmedchem.5b00407. Epub 2015 May 21. J Med Chem. 2015. PMID: 25953419
Synthetic phospholipids as specific substrates for plasma endothelial lipase.
Papillon JP, Pan M, Brousseau ME, Gilchrist MA, Lou C, Singh AK, Stawicki T, Thompson JE. Papillon JP, et al. Among authors: lou c. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3514-7. doi: 10.1016/j.bmcl.2016.06.032. Epub 2016 Jun 14. Bioorg Med Chem Lett. 2016. PMID: 27344207
Synthesis of biotinylated OSW-1.
Kang Y, Lou C, Ahmed KB, Huang P, Jin Z. Kang Y, et al. Among authors: lou c. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5166-8. doi: 10.1016/j.bmcl.2009.07.062. Epub 2009 Jul 14. Bioorg Med Chem Lett. 2009. PMID: 19640708 Free PMC article.
941 results