Ruiz FX - Search Results

1

Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10.

Ruiz FX, Cousido-Siah A, Porté S, Domínguez M, Crespo I, Rechlin C, Mitschler A, de Lera ÁR, Martín MJ, de la Fuente JÁ, Klebe G, Parés X, Farrés J, Podjarny A. Ruiz FX, et al. ChemMedChem. 2015 Dec;10(12):1989-2003. doi: 10.1002/cmdc.201500393. Epub 2015 Nov 9. ChemMedChem. 2015. PMID: 26549844

2

Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids.

Gallego O, Belyaeva OV, Porté S, Ruiz FX, Stetsenko AV, Shabrova EV, Kostereva NV, Farrés J, Parés X, Kedishvili NY. Gallego O, et al. Among authors: ruiz fx. Biochem J. 2006 Oct 1;399(1):101-9. doi: 10.1042/BJ20051988. Biochem J. 2006. PMID: 16787387 Free PMC article.

3

Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.

Gallego O, Ruiz FX, Ardèvol A, Domínguez M, Alvarez R, de Lera AR, Rovira C, Farrés J, Fita I, Parés X. Gallego O, et al. Among authors: ruiz fx. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20764-9. doi: 10.1073/pnas.0705659105. Epub 2007 Dec 17. Proc Natl Acad Sci U S A. 2007. PMID: 18087047 Free PMC article.

4

Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels.

Ruiz FX, Gallego O, Ardèvol A, Moro A, Domínguez M, Alvarez S, Alvarez R, de Lera AR, Rovira C, Fita I, Parés X, Farrés J. Ruiz FX, et al. Chem Biol Interact. 2009 Mar 16;178(1-3):171-7. doi: 10.1016/j.cbi.2008.10.027. Epub 2008 Oct 25. Chem Biol Interact. 2009. PMID: 19014918

5

Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde.

Ruiz FX, Moro A, Gallego O, Ardèvol A, Rovira C, Petrash JM, Parés X, Farrés J. Ruiz FX, et al. Chem Biol Interact. 2011 May 30;191(1-3):199-205. doi: 10.1016/j.cbi.2011.02.007. Epub 2011 Feb 15. Chem Biol Interact. 2011. PMID: 21329680 Free PMC article.

6

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

Ruiz FX, Porté S, Gallego O, Moro A, Ardèvol A, Del Río-Espínola A, Rovira C, Farrés J, Parés X. Ruiz FX, et al. Biochem J. 2011 Dec 15;440(3):335-44. doi: 10.1042/BJ20111286. Biochem J. 2011. PMID: 21851338

7

Biological role of aldo-keto reductases in retinoic Acid biosynthesis and signaling.

Ruiz FX, Porté S, Parés X, Farrés J. Ruiz FX, et al. Front Pharmacol. 2012 Apr 17;3:58. doi: 10.3389/fphar.2012.00058. eCollection 2012. Front Pharmacol. 2012. PMID: 22529810 Free PMC article.

8

Crystal packing modifies ligand binding affinity: the case of aldose reductase.

Cousido-Siah A, Petrova T, Hazemann I, Mitschler A, Ruiz FX, Howard E, Ginell S, Atmanene C, Van Dorsselaer A, Sanglier-Cianférani S, Joachimiak A, Podjarny A. Cousido-Siah A, et al. Among authors: ruiz fx. Proteins. 2012 Nov;80(11):2552-61. doi: 10.1002/prot.24136. Epub 2012 Jul 28. Proteins. 2012. PMID: 22752989 Free PMC article.

9

X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.

Ruiz FX, Cousido-Siah A, Mitschler A, Farrés J, Parés X, Podjarny A. Ruiz FX, et al. Chem Biol Interact. 2013 Feb 25;202(1-3):178-85. doi: 10.1016/j.cbi.2012.12.013. Epub 2013 Jan 4. Chem Biol Interact. 2013. PMID: 23295227

10

2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.

Golebiowski A, Paul Beckett R, Van Zandt M, Ji MK, Whitehouse D, Ryder TR, Jagdmann E, Andreoli M, Mazur A, Padmanilayam M, Cousido-Siah A, Mitschler A, Ruiz FX, Podjarny A, Schroeter H. Golebiowski A, et al. Among authors: ruiz fx. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2027-30. doi: 10.1016/j.bmcl.2013.02.024. Epub 2013 Feb 13. Bioorg Med Chem Lett. 2013. PMID: 23453840

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