Brinkmann-Chen S - Search Results

1

Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation.

Buller AR, Brinkmann-Chen S, Romney DK, Herger M, Murciano-Calles J, Arnold FH. Buller AR, et al. Among authors: brinkmann chen s. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14599-604. doi: 10.1073/pnas.1516401112. Epub 2015 Nov 9. Proc Natl Acad Sci U S A. 2015. PMID: 26553994 Free PMC article.

2

General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH.

Brinkmann-Chen S, Flock T, Cahn JK, Snow CD, Brustad EM, McIntosh JA, Meinhold P, Zhang L, Arnold FH. Brinkmann-Chen S, et al. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10946-51. doi: 10.1073/pnas.1306073110. Epub 2013 Jun 17. Proc Natl Acad Sci U S A. 2013. PMID: 23776225 Free PMC article.

3

Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase.

Herger M, van Roye P, Romney DK, Brinkmann-Chen S, Buller AR, Arnold FH. Herger M, et al. Among authors: brinkmann chen s. J Am Chem Soc. 2016 Jul 13;138(27):8388-91. doi: 10.1021/jacs.6b04836. Epub 2016 Jul 1. J Am Chem Soc. 2016. PMID: 27355405 Free PMC article.

4

A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation.

Murciano-Calles J, Romney DK, Brinkmann-Chen S, Buller AR, Arnold FH. Murciano-Calles J, et al. Among authors: brinkmann chen s. Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11577-81. doi: 10.1002/anie.201606242. Epub 2016 Aug 11. Angew Chem Int Ed Engl. 2016. PMID: 27510733 Free PMC article.

5

Engineered Biosynthesis of β-Alkyl Tryptophan Analogues.

Boville CE, Scheele RA, Koch P, Brinkmann-Chen S, Buller AR, Arnold FH. Boville CE, et al. Among authors: brinkmann chen s. Angew Chem Int Ed Engl. 2018 Nov 5;57(45):14764-14768. doi: 10.1002/anie.201807998. Epub 2018 Oct 12. Angew Chem Int Ed Engl. 2018. PMID: 30215880

6

Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes.

Cahn JK, Baumschlager A, Brinkmann-Chen S, Arnold FH. Cahn JK, et al. Protein Eng Des Sel. 2016 Jan;29(1):31-8. doi: 10.1093/protein/gzv057. Epub 2015 Oct 27. Protein Eng Des Sel. 2016. PMID: 26512129 Free PMC article.

7

Structural, functional, and spectroscopic characterization of the substrate scope of the novel nitrating cytochrome P450 TxtE.

Dodani SC, Cahn JK, Heinisch T, Brinkmann-Chen S, McIntosh JA, Arnold FH. Dodani SC, et al. Chembiochem. 2014 Oct 13;15(15):2259-67. doi: 10.1002/cbic.201402241. Epub 2014 Sep 2. Chembiochem. 2014. PMID: 25182183 Free PMC article.

8

Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases.

Cahn JK, Brinkmann-Chen S, Spatzal T, Wiig JA, Buller AR, Einsle O, Hu Y, Ribbe MW, Arnold FH. Cahn JK, et al. Biochem J. 2015 Jun 15;468(3):475-84. doi: 10.1042/BJ20150183. Epub 2015 Apr 7. Biochem J. 2015. PMID: 25849365 Free PMC article.

9

Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases.

Cahn JK, Brinkmann-Chen S, Buller AR, Arnold FH. Cahn JK, et al. Among authors: brinkmann chen s. Protein Sci. 2016 Jul;25(7):1241-8. doi: 10.1002/pro.2852. Epub 2015 Dec 21. Protein Sci. 2016. PMID: 26644020 Free PMC article.

10

Enantioselective, intermolecular benzylic C-H amination catalysed by an engineered iron-haem enzyme.

Prier CK, Zhang RK, Buller AR, Brinkmann-Chen S, Arnold FH. Prier CK, et al. Among authors: brinkmann chen s. Nat Chem. 2017 Jul;9(7):629-634. doi: 10.1038/nchem.2783. Epub 2017 May 29. Nat Chem. 2017. PMID: 28644476 Free PMC article.

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