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Page 1
Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.
Oprea TI, Sklar LA, Agola JO, Guo Y, Silberberg M, Roxby J, Vestling A, Romero E, Surviladze Z, Murray-Krezan C, Waller A, Ursu O, Hudson LG, Wandinger-Ness A. Oprea TI, et al. Among authors: ursu o. PLoS One. 2015 Nov 11;10(11):e0142182. doi: 10.1371/journal.pone.0142182. eCollection 2015. PLoS One. 2015. PMID: 26558612 Free PMC article.
Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.
Hong L, Kenney SR, Phillips GK, Simpson D, Schroeder CE, Nöth J, Romero E, Swanson S, Waller A, Strouse JJ, Carter M, Chigaev A, Ursu O, Oprea T, Hjelle B, Golden JE, Aubé J, Hudson LG, Buranda T, Sklar LA, Wandinger-Ness A. Hong L, et al. Among authors: ursu o. J Biol Chem. 2013 Mar 22;288(12):8531-8543. doi: 10.1074/jbc.M112.435941. Epub 2013 Feb 4. J Biol Chem. 2013. PMID: 23382385 Free PMC article.
A Pan-GTPase Inhibitor as a Molecular Probe.
Hong L, Guo Y, BasuRay S, Agola JO, Romero E, Simpson DS, Schroeder CE, Simons P, Waller A, Garcia M, Carter M, Ursu O, Gouveia K, Golden JE, Aubé J, Wandinger-Ness A, Sklar LA. Hong L, et al. Among authors: ursu o. PLoS One. 2015 Aug 6;10(8):e0134317. doi: 10.1371/journal.pone.0134317. eCollection 2015. PLoS One. 2015. PMID: 26247207 Free PMC article.
Activation of Rho Family GTPases by Small Molecules.
Palsuledesai CC, Surviladze Z, Waller A, Miscioscia TF, Guo Y, Wu Y, Strouse J, Romero E, Salas VM, Curpan R, Young S, Carter M, Foutz T, Galochkina Z, Ames H, Haynes MK, Edwards BS, Nicolotti O, Luo L, Ursu O, Bologa CG, Oprea TI, Wandinger-Ness A, Sklar LA. Palsuledesai CC, et al. Among authors: ursu o. ACS Chem Biol. 2018 Jun 15;13(6):1514-1524. doi: 10.1021/acschembio.8b00038. Epub 2018 May 24. ACS Chem Biol. 2018. PMID: 29746086 Free PMC article.
Conformational mAb as a tool for integrin ligand discovery.
Njus BH, Chigaev A, Waller A, Wlodek D, Ostopovici-Halip L, Ursu O, Wang W, Oprea TI, Bologa CG, Sklar LA. Njus BH, et al. Among authors: ursu o. Assay Drug Dev Technol. 2009 Oct;7(5):507-15. doi: 10.1089/adt.2009.0203. Assay Drug Dev Technol. 2009. PMID: 19754304 Free PMC article.
Model-free drug-likeness from fragments.
Ursu O, Oprea TI. Ursu O, et al. J Chem Inf Model. 2010 Aug 23;50(8):1387-94. doi: 10.1021/ci100202p. J Chem Inf Model. 2010. PMID: 20726597
Drug Repurposing from an Academic Perspective.
Oprea TI, Bauman JE, Bologa CG, Buranda T, Chigaev A, Edwards BS, Jarvik JW, Gresham HD, Haynes MK, Hjelle B, Hromas R, Hudson L, Mackenzie DA, Muller CY, Reed JC, Simons PC, Smagley Y, Strouse J, Surviladze Z, Thompson T, Ursu O, Waller A, Wandinger-Ness A, Winter SS, Wu Y, Young SM, Larson RS, Willman C, Sklar LA. Oprea TI, et al. Among authors: ursu o. Drug Discov Today Ther Strateg. 2011 Winter;8(3-4):61-69. doi: 10.1016/j.ddstr.2011.10.002. Drug Discov Today Ther Strateg. 2011. PMID: 22368688 Free PMC article.
A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry.
Strouse JJ, Ivnitski-Steele I, Khawaja HM, Perez D, Ricci J, Yao T, Weiner WS, Schroeder CE, Simpson DS, Maki BE, Li K, Golden JE, Foutz TD, Waller A, Evangelisti AM, Young SM, Chavez SE, Garcia MJ, Ursu O, Bologa CG, Carter MB, Salas VM, Gouveia K, Tegos GP, Oprea TI, Edwards BS, Aubé J, Larson RS, Sklar LA. Strouse JJ, et al. Among authors: ursu o. J Biomol Screen. 2013 Jan;18(1):26-38. doi: 10.1177/1087057112456875. Epub 2012 Aug 24. J Biomol Screen. 2013. PMID: 22923785 Free PMC article.
Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters.
Strouse JJ, Ivnitski-Steele I, Waller A, Young SM, Perez D, Evangelisti AM, Ursu O, Bologa CG, Carter MB, Salas VM, Tegos G, Larson RS, Oprea TI, Edwards BS, Sklar LA. Strouse JJ, et al. Among authors: ursu o. Anal Biochem. 2013 Jun 1;437(1):77-87. doi: 10.1016/j.ab.2013.02.018. Epub 2013 Mar 5. Anal Biochem. 2013. PMID: 23470221 Free PMC article.
75 results