van Vugt MA - Search Results

1

A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity.

Heijink AM, Blomen VA, Bisteau X, Degener F, Matsushita FY, Kaldis P, Foijer F, van Vugt MA. Heijink AM, et al. Among authors: van vugt ma. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15160-5. doi: 10.1073/pnas.1505283112. Epub 2015 Nov 23. Proc Natl Acad Sci U S A. 2015. PMID: 26598692 Free PMC article.

2

Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling.

van Harn T, Foijer F, van Vugt M, Banerjee R, Yang F, Oostra A, Joenje H, te Riele H. van Harn T, et al. Genes Dev. 2010 Jul 1;24(13):1377-88. doi: 10.1101/gad.580710. Epub 2010 Jun 15. Genes Dev. 2010. PMID: 20551164 Free PMC article.

3

Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination.

Krajewska M, Heijink AM, Bisselink YJ, Seinstra RI, Silljé HH, de Vries EG, van Vugt MA. Krajewska M, et al. Among authors: van vugt ma. Oncogene. 2013 Jun 13;32(24):3001-8. doi: 10.1038/onc.2012.296. Epub 2012 Jul 16. Oncogene. 2013. PMID: 22797065

4

The DNA damage response during mitosis.

Heijink AM, Krajewska M, van Vugt MA. Heijink AM, et al. Among authors: van vugt ma. Mutat Res. 2013 Oct;750(1-2):45-55. doi: 10.1016/j.mrfmmm.2013.07.003. Epub 2013 Jul 21. Mutat Res. 2013. PMID: 23880065 Review.

5

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.

Schoonen PM, Talens F, Stok C, Gogola E, Heijink AM, Bouwman P, Foijer F, Tarsounas M, Blatter S, Jonkers J, Rottenberg S, van Vugt MATM. Schoonen PM, et al. Nat Commun. 2017 Jul 17;8:15981. doi: 10.1038/ncomms15981. Nat Commun. 2017. PMID: 28714471 Free PMC article.

6

Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma.

Zomerman WW, Plasschaert SLA, Conroy S, Scherpen FJ, Meeuwsen-de Boer TGJ, Lourens HJ, Guerrero Llobet S, Smit MJ, Slagter-Menkema L, Seitz A, Gidding CEM, Hulleman E, Wesseling P, Meijer L, van Kempen LC, van den Berg A, Warmerdam DO, Kruyt FAE, Foijer F, van Vugt MATM, den Dunnen WFA, Hoving EW, Guryev V, de Bont ESJM, Bruggeman SWM. Zomerman WW, et al. Cell Rep. 2018 Mar 20;22(12):3206-3216. doi: 10.1016/j.celrep.2018.02.089. Cell Rep. 2018. PMID: 29562177 Free article.

7

TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells.

van Gijn SE, Wierenga E, van den Tempel N, Kok YP, Heijink AM, Spierings DCJ, Foijer F, van Vugt MATM, Fehrmann RSN. van Gijn SE, et al. Oncogene. 2019 Feb;38(6):852-867. doi: 10.1038/s41388-018-0470-2. Epub 2018 Sep 3. Oncogene. 2019. PMID: 30177840 Free PMC article.

8

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.

Heijink AM, Talens F, Jae LT, van Gijn SE, Fehrmann RSN, Brummelkamp TR, van Vugt MATM. Heijink AM, et al. Nat Commun. 2019 Jan 9;10(1):100. doi: 10.1038/s41467-018-07927-y. Nat Commun. 2019. PMID: 30626869 Free PMC article.

9

RIF1 promotes replication fork protection and efficient restart to maintain genome stability.

Mukherjee C, Tripathi V, Manolika EM, Heijink AM, Ricci G, Merzouk S, de Boer HR, Demmers J, van Vugt MATM, Ray Chaudhuri A. Mukherjee C, et al. Nat Commun. 2019 Jul 23;10(1):3287. doi: 10.1038/s41467-019-11246-1. Nat Commun. 2019. PMID: 31337767 Free PMC article.

10

Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity.

Heijink AM, Everts M, Honeywell ME, Richards R, Kok YP, de Vries EGE, Lee MJ, van Vugt MATM. Heijink AM, et al. Cell Rep. 2019 Aug 27;28(9):2345-2357.e5. doi: 10.1016/j.celrep.2019.07.070. Cell Rep. 2019. PMID: 31461651 Free PMC article.

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