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Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Shadrick WR, Slavish PJ, Chai SC, Waddell B, Connelly M, Low JA, Tallant C, Young BM, Bharatham N, Knapp S, Boyd VA, Morfouace M, Roussel MF, Chen T, Lee RE, Kiplin Guy R, Shelat AA, Potter PM. Shadrick WR, et al. Among authors: young bm. Bioorg Med Chem. 2018 Jan 1;26(1):25-36. doi: 10.1016/j.bmc.2017.10.042. Epub 2017 Nov 4. Bioorg Med Chem. 2018. PMID: 29170024 Free PMC article.
Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.
Slavish PJ, Chi L, Yun MK, Tsurkan L, Martinez NE, Jonchere B, Chai SC, Connelly M, Waddell MB, Das S, Neale G, Li Z, Shadrick WR, Olsen RR, Freeman KW, Low JA, Price JE, Young BM, Bharatham N, Boyd VA, Yang J, Lee RE, Morfouace M, Roussel MF, Chen T, Savic D, Guy RK, White SW, Shelat AA, Potter PM. Slavish PJ, et al. Among authors: young bm. Cancer Res. 2020 Sep 1;80(17):3507-3518. doi: 10.1158/0008-5472.CAN-19-3934. Epub 2020 Jul 10. Cancer Res. 2020. PMID: 32651255 Free PMC article.
Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators.
Nishiguchi G, Keramatnia F, Min J, Chang Y, Jonchere B, Das S, Actis M, Price J, Chepyala D, Young B, McGowan K, Slavish PJ, Mayasundari A, Jarusiewicz JA, Yang L, Li Y, Fu X, Garrett SH, Papizan JB, Kodali K, Peng J, Pruett Miller SM, Roussel MF, Mullighan C, Fischer M, Rankovic Z. Nishiguchi G, et al. J Med Chem. 2021 Jun 10;64(11):7296-7311. doi: 10.1021/acs.jmedchem.0c01313. Epub 2021 May 27. J Med Chem. 2021. PMID: 34042448 Free PMC article.
Recent Advances with KDM4 Inhibitors and Potential Applications.
Wu Q, Young B, Wang Y, Davidoff AM, Rankovic Z, Yang J. Wu Q, et al. J Med Chem. 2022 Jul 28;65(14):9564-9579. doi: 10.1021/acs.jmedchem.2c00680. Epub 2022 Jul 15. J Med Chem. 2022. PMID: 35838529 Free PMC article. Review.
Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox.
Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM. Yang J, et al. Cancer Res. 2017 Sep 1;77(17):4626-4638. doi: 10.1158/0008-5472.CAN-16-0826. Epub 2017 Jul 6. Cancer Res. 2017. PMID: 28684529 Free PMC article.
Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.
Min J, Mayasundari A, Keramatnia F, Jonchere B, Yang SW, Jarusiewicz J, Actis M, Das S, Young B, Slavish J, Yang L, Li Y, Fu X, Garrett SH, Yun MK, Li Z, Nithianantham S, Chai S, Chen T, Shelat A, Lee RE, Nishiguchi G, White SW, Roussel MF, Potts PR, Fischer M, Rankovic Z. Min J, et al. Angew Chem Int Ed Engl. 2021 Dec 13;60(51):26663-26670. doi: 10.1002/anie.202108848. Epub 2021 Nov 16. Angew Chem Int Ed Engl. 2021. PMID: 34614283 Free PMC article.
Continuous collective analysis of chemical reactions.
Hu M, Yang L, Twarog N, Ochoada J, Li Y, Vrettos EI, Torres-Hernandez AX, Martinez JB, Bhatia J, Young BM, Price J, McGowan K, Nguyen TH, Shi Z, Anyanwu M, Rimmer MA, Mercer S, Rankovic Z, Shelat AA, Blair DJ. Hu M, et al. Among authors: young bm. Nature. 2024 Dec;636(8042):374-379. doi: 10.1038/s41586-024-08211-4. Epub 2024 Dec 11. Nature. 2024. PMID: 39663496
118 results