Lohse S - Search Results

1

An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo.

Lohse S, Meyer S, Meulenbroek LA, Jansen JH, Nederend M, Kretschmer A, Klausz K, Möginger U, Derer S, Rösner T, Kellner C, Schewe D, Sondermann P, Tiwari S, Kolarich D, Peipp M, Leusen JH, Valerius T. Lohse S, et al. Cancer Res. 2016 Jan 15;76(2):403-17. doi: 10.1158/0008-5472.CAN-15-1232. Epub 2015 Dec 3. Cancer Res. 2016. PMID: 26634925

2

Serum-free production and purification of chimeric IgA antibodies.

Beyer T, Lohse S, Berger S, Peipp M, Valerius T, Dechant M. Beyer T, et al. Among authors: lohse s. J Immunol Methods. 2009 Jul 31;346(1-2):26-37. doi: 10.1016/j.jim.2009.05.002. Epub 2009 May 7. J Immunol Methods. 2009. PMID: 19427867

3

Human IgG2 antibodies against epidermal growth factor receptor effectively trigger antibody-dependent cellular cytotoxicity but, in contrast to IgG1, only by cells of myeloid lineage.

Schneider-Merck T, Lammerts van Bueren JJ, Berger S, Rossen K, van Berkel PH, Derer S, Beyer T, Lohse S, Bleeker WK, Peipp M, Parren PW, van de Winkel JG, Valerius T, Dechant M. Schneider-Merck T, et al. Among authors: lohse s. J Immunol. 2010 Jan 1;184(1):512-20. doi: 10.4049/jimmunol.0900847. Epub 2009 Nov 30. J Immunol. 2010. PMID: 19949082

4

Fc-engineered EGF-R antibodies mediate improved antibody-dependent cellular cytotoxicity (ADCC) against KRAS-mutated tumor cells.

Schlaeth M, Berger S, Derer S, Klausz K, Lohse S, Dechant M, Lazar GA, Schneider-Merck T, Peipp M, Valerius T. Schlaeth M, et al. Among authors: lohse s. Cancer Sci. 2010 May;101(5):1080-8. doi: 10.1111/j.1349-7006.2010.01505.x. Epub 2010 Jan 20. Cancer Sci. 2010. PMID: 20331636 Free PMC article.

5

Impact of human IgA antibodies on complement-dependent cytotoxicity mediated by combinations of EGF-R-directed antibodies.

Lohse S, Peipp M, Beyer T, Valerius T, Dechant M. Lohse S, et al. Arch Immunol Ther Exp (Warsz). 2010 Aug;58(4):303-12. doi: 10.1007/s00005-010-0081-2. Epub 2010 May 28. Arch Immunol Ther Exp (Warsz). 2010. PMID: 20508996 Free article.

6

Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing.

Lohse S, Derer S, Beyer T, Klausz K, Peipp M, Leusen JH, van de Winkel JG, Dechant M, Valerius T. Lohse S, et al. J Immunol. 2011 Mar 15;186(6):3770-8. doi: 10.4049/jimmunol.1003082. Epub 2011 Feb 11. J Immunol. 2011. PMID: 21317397

7

Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy.

Bakema JE, Ganzevles SH, Fluitsma DM, Schilham MW, Beelen RH, Valerius T, Lohse S, Glennie MJ, Medema JP, van Egmond M. Bakema JE, et al. Among authors: lohse s. J Immunol. 2011 Jul 15;187(2):726-32. doi: 10.4049/jimmunol.1002581. Epub 2011 Jun 8. J Immunol. 2011. PMID: 21653835

8

Complement-mediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor (EGFR) and its variant III (EGFRvIII).

Klausz K, Berger S, Lammerts van Bueren JJ, Derer S, Lohse S, Dechant M, van de Winkel JG, Peipp M, Parren PW, Valerius T. Klausz K, et al. Among authors: lohse s. Cancer Sci. 2011 Oct;102(10):1761-8. doi: 10.1111/j.1349-7006.2011.02019.x. Epub 2011 Aug 4. Cancer Sci. 2011. PMID: 21718386 Free article.

9

Oncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expression.

Derer S, Berger S, Schlaeth M, Schneider-Merck T, Klausz K, Lohse S, Overdijk MB, Dechant M, Kellner C, Nagelmeier I, Scheel AH, Lammerts van Bueren JJ, van de Winkel JG, Parren PW, Peipp M, Valerius T. Derer S, et al. Among authors: lohse s. Neoplasia. 2012 Mar;14(3):190-205. doi: 10.1593/neo.111636. Neoplasia. 2012. PMID: 22496619 Free PMC article.

10

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

Lohse S, Brunke C, Derer S, Peipp M, Boross P, Kellner C, Beyer T, Dechant M, van der Winkel JG, Leusen JH, Valerius T. Lohse S, et al. J Biol Chem. 2012 Jul 20;287(30):25139-50. doi: 10.1074/jbc.M112.353060. Epub 2012 Jun 7. J Biol Chem. 2012. PMID: 22679018 Free PMC article.

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