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Page 1
Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.
de Waal L, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, Shamji AF, Koehler AN, Schenone M, Burgin AB, Schreiber SL, Greulich H, Meyerson M. de Waal L, et al. Among authors: schenone m. Nat Chem Biol. 2016 Feb;12(2):102-8. doi: 10.1038/nchembio.1984. Epub 2015 Dec 14. Nat Chem Biol. 2016. PMID: 26656089 Free PMC article.
Identifying the proteins to which small-molecule probes and drugs bind in cells.
Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, Mani DR, Kuai L, Wang X, Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub TR, Gould RJ, Schreiber SL, Carr SA. Ong SE, et al. Among authors: schenone m. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4617-22. doi: 10.1073/pnas.0900191106. Epub 2009 Mar 2. Proc Natl Acad Sci U S A. 2009. PMID: 19255428 Free PMC article.
Empirical Bayes analysis of quantitative proteomics experiments.
Margolin AA, Ong SE, Schenone M, Gould R, Schreiber SL, Carr SA, Golub TR. Margolin AA, et al. Among authors: schenone m. PLoS One. 2009 Oct 14;4(10):e7454. doi: 10.1371/journal.pone.0007454. PLoS One. 2009. PMID: 19829701 Free PMC article.
Selective killing of cancer cells by a small molecule targeting the stress response to ROS.
Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Raj L, et al. Among authors: schenone m. Nature. 2011 Jul 13;475(7355):231-4. doi: 10.1038/nature10167. Nature. 2011. Retraction in: Nature. 2018 Sep;561(7723):420. doi: 10.1038/s41586-018-0284-y. PMID: 21753854 Free PMC article. Retracted.
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Goldberg L, Birger Y, Izraeli S, Gamis AS, Smith FO, Woods WG, Taub J, Scherer CA, Bradner JE, Goh BC, Mercher T, Carpenter AE, Gould RJ, Clemons PA, Carr SA, Root DE, Schreiber SL, Stern AM, Crispino JD. Wen Q, et al. Among authors: schenone m. Cell. 2012 Aug 3;150(3):575-89. doi: 10.1016/j.cell.2012.06.032. Cell. 2012. PMID: 22863010 Free PMC article.
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.
Krönke J, Udeshi ND, Narla A, Grauman P, Hurst SN, McConkey M, Svinkina T, Heckl D, Comer E, Li X, Ciarlo C, Hartman E, Munshi N, Schenone M, Schreiber SL, Carr SA, Ebert BL. Krönke J, et al. Among authors: schenone m. Science. 2014 Jan 17;343(6168):301-5. doi: 10.1126/science.1244851. Epub 2013 Nov 29. Science. 2014. PMID: 24292625 Free PMC article.
Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling.
Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dančík V, Ciarlo C, Paulk J, Dai M, Reddy C, Sun H, Young M, Donato N, Jaffe J, Clemons PA, Palmer M, Carr SA, Schreiber SL, Wagner BK. Chou DH, et al. Among authors: schenone m. J Am Chem Soc. 2015 Jun 24;137(24):7929-34. doi: 10.1021/jacs.5b04284. Epub 2015 Jun 15. J Am Chem Soc. 2015. PMID: 26042473 Free PMC article.
Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.
Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo SY, Villablanca EJ, Fagbami L, Oosting M, Kumar V, Schenone M, Carr SA, Joosten LA, Vyas JM, Daly MJ, Netea MG, Brown GD, Wijmenga C, Xavier RJ. Begun J, et al. Among authors: schenone m. Cell Rep. 2015 Jun 30;11(12):1905-18. doi: 10.1016/j.celrep.2015.05.045. Epub 2015 Jun 18. Cell Rep. 2015. PMID: 26095365 Free PMC article.
135 results