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Page 1
Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist.
Serradeil-Le Gal C, Wagnon J, Simiand J, Griebel G, Lacour C, Guillon G, Barberis C, Brossard G, Soubrié P, Nisato D, Pascal M, Pruss R, Scatton B, Maffrand JP, Le Fur G. Serradeil-Le Gal C, et al. Among authors: wagnon j. J Pharmacol Exp Ther. 2002 Mar;300(3):1122-30. doi: 10.1124/jpet.300.3.1122. J Pharmacol Exp Ther. 2002. PMID: 11861823
Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders.
Griebel G, Simiand J, Serradeil-Le Gal C, Wagnon J, Pascal M, Scatton B, Maffrand JP, Soubrie P. Griebel G, et al. Among authors: wagnon j. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6370-5. doi: 10.1073/pnas.092012099. Epub 2002 Apr 16. Proc Natl Acad Sci U S A. 2002. PMID: 11959912 Free PMC article.
Biological characterization of rodent and human vasopressin V1b receptors using SSR-149415, a nonpeptide V1b receptor ligand.
Serradeil-Le Gal C, Raufaste D, Derick S, Blankenstein J, Allen J, Pouzet B, Pascal M, Wagnon J, Ventura MA. Serradeil-Le Gal C, et al. Among authors: wagnon j. Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R938-49. doi: 10.1152/ajpregu.00062.2007. Epub 2007 May 23. Am J Physiol Regul Integr Comp Physiol. 2007. PMID: 17522130 Free article.
64 results