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The vascular endothelial growth factor receptor inhibitor sunitinib causes a preeclampsia-like syndrome with activation of the endothelin system.
Kappers MH, Smedts FM, Horn T, van Esch JH, Sleijfer S, Leijten F, Wesseling S, Strevens H, Jan Danser AH, van den Meiracker AH. Kappers MH, et al. Among authors: van den meiracker ah, van esch jh. Hypertension. 2011 Aug;58(2):295-302. doi: 10.1161/HYPERTENSIONAHA.111.173559. Epub 2011 Jun 13. Hypertension. 2011. PMID: 21670421
Sunitinib-induced hypothyroidism is due to induction of type 3 deiodinase activity and thyroidal capillary regression.
Kappers MH, van Esch JH, Smedts FM, de Krijger RR, Eechoute K, Mathijssen RH, Sleijfer S, Leijten F, Danser AH, van den Meiracker AH, Visser TJ. Kappers MH, et al. Among authors: van den meiracker ah, van esch jh. J Clin Endocrinol Metab. 2011 Oct;96(10):3087-94. doi: 10.1210/jc.2011-1172. Epub 2011 Aug 3. J Clin Endocrinol Metab. 2011. PMID: 21816788
Endothelin-1 and antiangiogenesis.
Lankhorst S, Danser AH, van den Meiracker AH. Lankhorst S, et al. Among authors: van den meiracker ah. Am J Physiol Regul Integr Comp Physiol. 2016 Feb 1;310(3):R230-4. doi: 10.1152/ajpregu.00373.2015. Epub 2015 Oct 28. Am J Physiol Regul Integr Comp Physiol. 2016. PMID: 26511523 Free article. Review.
260 results