Ali A - Search Results

1

Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172.

Soumana DI, Kurt Yilmaz N, Prachanronarong KL, Aydin C, Ali A, Schiffer CA. Soumana DI, et al. Among authors: ali a. ACS Chem Biol. 2016 Apr 15;11(4):900-9. doi: 10.1021/acschembio.5b00647. Epub 2016 Jan 6. ACS Chem Biol. 2016. PMID: 26682473 Free PMC article.

2

Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands.

Ali A, Reddy GS, Cao H, Anjum SG, Nalam MN, Schiffer CA, Rana TM. Ali A, et al. J Med Chem. 2006 Dec 14;49(25):7342-56. doi: 10.1021/jm060666p. J Med Chem. 2006. PMID: 17149864

3

Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis.

Chellappan S, Kiran Kumar Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Kairys V, Fernandes MX, Altman MD, Tidor B, Rana TM, Schiffer CA, Gilson MK. Chellappan S, et al. Among authors: ali a. Chem Biol Drug Des. 2007 May;69(5):298-313. doi: 10.1111/j.1747-0285.2007.00514.x. Chem Biol Drug Des. 2007. PMID: 17539822

4

Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres.

Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Nathans RS, Schiffer CA, Rana TM. Reddy GS, et al. Among authors: ali a. J Med Chem. 2007 Sep 6;50(18):4316-28. doi: 10.1021/jm070284z. Epub 2007 Aug 16. J Med Chem. 2007. PMID: 17696512 Free PMC article.

5

HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.

Altman MD, Ali A, Reddy GS, Nalam MN, Anjum SG, Cao H, Chellappan S, Kairys V, Fernandes MX, Gilson MK, Schiffer CA, Rana TM, Tidor B. Altman MD, et al. Among authors: ali a. J Am Chem Soc. 2008 May 14;130(19):6099-113. doi: 10.1021/ja076558p. Epub 2008 Apr 16. J Am Chem Soc. 2008. PMID: 18412349 Free PMC article.

6

Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.

Nalam MN, Ali A, Altman MD, Reddy GS, Chellappan S, Kairys V, Ozen A, Cao H, Gilson MK, Tidor B, Rana TM, Schiffer CA. Nalam MN, et al. Among authors: ali a. J Virol. 2010 May;84(10):5368-78. doi: 10.1128/JVI.02531-09. Epub 2010 Mar 17. J Virol. 2010. PMID: 20237088 Free PMC article.

7

Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones.

Ali A, Reddy GS, Nalam MN, Anjum SG, Cao H, Schiffer CA, Rana TM. Ali A, et al. J Med Chem. 2010 Nov 11;53(21):7699-708. doi: 10.1021/jm1008743. J Med Chem. 2010. PMID: 20958050 Free PMC article.

8

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.

Romano KP, Ali A, Royer WE, Schiffer CA. Romano KP, et al. Among authors: ali a. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20986-91. doi: 10.1073/pnas.1006370107. Epub 2010 Nov 17. Proc Natl Acad Sci U S A. 2010. PMID: 21084633 Free PMC article.

9

Molecular Basis for Drug Resistance in HIV-1 Protease.

Ali A, Bandaranayake RM, Cai Y, King NM, Kolli M, Mittal S, Murzycki JF, Nalam MNL, Nalivaika EA, Özen A, Prabu-Jeyabalan MM, Thayer K, Schiffer CA. Ali A, et al. Viruses. 2010 Nov;2(11):2509-2535. doi: 10.3390/v2112509. Epub 2010 Nov 12. Viruses. 2010. PMID: 21994628 Free PMC article.

10

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, Schiffer CA, Harris RS. Li M, et al. Among authors: ali a. ACS Chem Biol. 2012 Mar 16;7(3):506-17. doi: 10.1021/cb200440y. Epub 2012 Jan 17. ACS Chem Biol. 2012. PMID: 22181350 Free PMC article.

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