Abraham SJ - Search Results

1

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

Chavan TS, Jang H, Khavrutskii L, Abraham SJ, Banerjee A, Freed BC, Johannessen L, Tarasov SG, Gaponenko V, Nussinov R, Tarasova NI. Chavan TS, et al. Among authors: abraham sj. Biophys J. 2015 Dec 15;109(12):2602-2613. doi: 10.1016/j.bpj.2015.09.034. Biophys J. 2015. PMID: 26682817 Free PMC article.

2

Application of reductive ¹³C-methylation of lysines to enhance the sensitivity of conventional NMR methods.

Chavan TS, Abraham S, Gaponenko V. Chavan TS, et al. Molecules. 2013 Jun 18;18(6):7103-19. doi: 10.3390/molecules18067103. Molecules. 2013. PMID: 23778120 Free PMC article.

3

The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin.

Abraham SJ, Nolet RP, Calvert RJ, Anderson LM, Gaponenko V. Abraham SJ, et al. Biochemistry. 2009 Aug 18;48(32):7575-83. doi: 10.1021/bi900769j. Biochemistry. 2009. PMID: 19583261 Free PMC article.

4

Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region.

Jang H, Abraham SJ, Chavan TS, Hitchinson B, Khavrutskii L, Tarasova NI, Nussinov R, Gaponenko V. Jang H, et al. Among authors: abraham sj. J Biol Chem. 2015 Apr 10;290(15):9465-77. doi: 10.1074/jbc.M114.620724. Epub 2015 Feb 24. J Biol Chem. 2015. PMID: 25713064 Free PMC article.

5

Expression, purification, and characterization of soluble K-Ras4B for structural analysis.

Abraham SJ, Muhamed I, Nolet R, Yeung F, Gaponenko V. Abraham SJ, et al. Protein Expr Purif. 2010 Oct;73(2):125-31. doi: 10.1016/j.pep.2010.05.015. Epub 2010 Jun 8. Protein Expr Purif. 2010. PMID: 20566322

6

Detection of protein-ligand interactions by NMR using reductive methylation of lysine residues.

Abraham SJ, Hoheisel S, Gaponenko V. Abraham SJ, et al. J Biomol NMR. 2008 Oct;42(2):143-8. doi: 10.1007/s10858-008-9274-y. Epub 2008 Sep 26. J Biomol NMR. 2008. PMID: 18819009 Free article.

7

Differences in lysine pKa values may be used to improve NMR signal dispersion in reductively methylated proteins.

Abraham SJ, Kobayashi T, Solaro RJ, Gaponenko V. Abraham SJ, et al. J Biomol NMR. 2009 Apr;43(4):239-46. doi: 10.1007/s10858-009-9306-2. Epub 2009 Mar 12. J Biomol NMR. 2009. PMID: 19280122 Free PMC article.

8

Revealing an outward-facing open conformational state in a CLC Cl(-)/H(+) exchange transporter.

Khantwal CM, Abraham SJ, Han W, Jiang T, Chavan TS, Cheng RC, Elvington SM, Liu CW, Mathews II, Stein RA, Mchaourab HS, Tajkhorshid E, Maduke M. Khantwal CM, et al. Among authors: abraham sj. Elife. 2016 Jan 22;5:e11189. doi: 10.7554/eLife.11189. Elife. 2016. PMID: 26799336 Free PMC article.

9

First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand.

Palmioli A, Sacco E, Abraham S, Thomas CJ, Di Domizio A, De Gioia L, Gaponenko V, Vanoni M, Peri F. Palmioli A, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4217-22. doi: 10.1016/j.bmcl.2009.05.107. Epub 2009 May 30. Bioorg Med Chem Lett. 2009. PMID: 19515561 Free article.

10

A designed inhibitor of a CLC antiporter blocks function through a unique binding mode.

Howery AE, Elvington S, Abraham SJ, Choi KH, Dworschak-Simpson S, Phillips S, Ryan CM, Sanford RL, Almqvist J, Tran K, Chew TA, Zachariae U, Andersen OS, Whitelegge J, Matulef K, Du Bois J, Maduke MC. Howery AE, et al. Among authors: abraham sj. Chem Biol. 2012 Nov 21;19(11):1460-70. doi: 10.1016/j.chembiol.2012.09.017. Chem Biol. 2012. PMID: 23177200 Free PMC article.

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