Inhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear.
Gumucio JP, Flood MD, Bedi A, Kramer HF, Russell AJ, Mendias CL.
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Bone Joint Res. 2017 Jan;6(1):57-65. doi: 10.1302/2046-3758.61.BJR-2016-0232.R1.
Bone Joint Res. 2017.
PMID: 28108482
Free PMC article.
There was a decrease in the expression of several gene transcripts related to matrix accumulation and fibrosis, and a 50% decrease in collagen content in both treated groups compared with controls. ...PHD inhibition may be beneficial for connective tissue injuries i …
There was a decrease in the expression of several gene transcripts related to matrix accumulation and fibrosis, and a 50% decr …