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Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.
Federico S, Ciancetta A, Sabbadin D, Paoletta S, Pastorin G, Cacciari B, Klotz KN, Moro S, Spalluto G. Federico S, et al. Among authors: ciancetta a. J Med Chem. 2012 Nov 26;55(22):9654-68. doi: 10.1021/jm300899q. Epub 2012 Nov 9. J Med Chem. 2012. PMID: 23098605
7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A₁ and A(2A) adenosine receptors. Molecular modeling and pharmacological studies.
Squarcialupi L, Colotta V, Catarzi D, Varano F, Betti M, Varani K, Vincenzi F, Borea PA, Porta N, Ciancetta A, Moro S. Squarcialupi L, et al. Among authors: ciancetta a. Eur J Med Chem. 2014 Sep 12;84:614-27. doi: 10.1016/j.ejmech.2014.07.060. Epub 2014 Jul 19. Eur J Med Chem. 2014. PMID: 25063944
The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives.
Federico S, Redenti S, Sturlese M, Ciancetta A, Kachler S, Klotz KN, Cacciari B, Moro S, Spalluto G. Federico S, et al. Among authors: ciancetta a. PLoS One. 2015 Dec 1;10(12):e0143504. doi: 10.1371/journal.pone.0143504. eCollection 2015. PLoS One. 2015. PMID: 26625265 Free PMC article.
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.
Squarcialupi L, Colotta V, Catarzi D, Varano F, Filacchioni G, Varani K, Corciulo C, Vincenzi F, Borea PA, Ghelardini C, Di Cesare Mannelli L, Ciancetta A, Moro S. Squarcialupi L, et al. Among authors: ciancetta a. J Med Chem. 2013 Mar 28;56(6):2256-69. doi: 10.1021/jm400068e. Epub 2013 Mar 7. J Med Chem. 2013. PMID: 23427825
52 results