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Page 1
In vivo gene editing in dystrophic mouse muscle and muscle stem cells.
Tabebordbar M, Zhu K, Cheng JKW, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ. Tabebordbar M, et al. Among authors: widrick jj. Science. 2016 Jan 22;351(6271):407-411. doi: 10.1126/science.aad5177. Epub 2015 Dec 31. Science. 2016. PMID: 26721686 Free PMC article.
Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling.
Kawahara G, Gasperini MJ, Myers JA, Widrick JJ, Eran A, Serafini PR, Alexander MS, Pletcher MT, Morris CA, Kunkel LM. Kawahara G, et al. Among authors: widrick jj. Hum Mol Genet. 2014 Apr 1;23(7):1869-78. doi: 10.1093/hmg/ddt579. Epub 2013 Nov 13. Hum Mol Genet. 2014. PMID: 24234649 Free PMC article.
The SINE Compound KPT-350 Blocks Dystrophic Pathologies in DMD Zebrafish and Mice.
Hightower RM, Reid AL, Gibbs DE, Wang Y, Widrick JJ, Kunkel LM, Kastenschmidt JM, Villalta SA, van Groen T, Chang H, Gornisiewicz S, Landesman Y, Tamir S, Alexander MS. Hightower RM, et al. Among authors: widrick jj. Mol Ther. 2020 Jan 8;28(1):189-201. doi: 10.1016/j.ymthe.2019.08.016. Epub 2019 Sep 3. Mol Ther. 2020. PMID: 31628052 Free PMC article.
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species.
Tabebordbar M, Lagerborg KA, Stanton A, King EM, Ye S, Tellez L, Krunnfusz A, Tavakoli S, Widrick JJ, Messemer KA, Troiano EC, Moghadaszadeh B, Peacker BL, Leacock KA, Horwitz N, Beggs AH, Wagers AJ, Sabeti PC. Tabebordbar M, et al. Among authors: widrick jj. Cell. 2021 Sep 16;184(19):4919-4938.e22. doi: 10.1016/j.cell.2021.08.028. Epub 2021 Sep 9. Cell. 2021. PMID: 34506722 Free PMC article.
miR-486 is essential for muscle function and suppresses a dystrophic transcriptome.
Samani A, Hightower RM, Reid AL, English KG, Lopez MA, Doyle JS, Conklin MJ, Schneider DA, Bamman MM, Widrick JJ, Crossman DK, Xie M, Jee D, Lai EC, Alexander MS. Samani A, et al. Among authors: widrick jj. Life Sci Alliance. 2022 May 5;5(9):e202101215. doi: 10.26508/lsa.202101215. Print 2022 Sep. Life Sci Alliance. 2022. PMID: 35512829 Free PMC article.
Muscle dysfunction in a zebrafish model of Duchenne muscular dystrophy.
Widrick JJ, Alexander MS, Sanchez B, Gibbs DE, Kawahara G, Beggs AH, Kunkel LM. Widrick JJ, et al. Physiol Genomics. 2016 Nov 1;48(11):850-860. doi: 10.1152/physiolgenomics.00088.2016. Epub 2016 Oct 7. Physiol Genomics. 2016. PMID: 27764767 Free PMC article.
88 results