Desideri A - Search Results

1

Inhibition of human DNA topoisomerase IB by nonmutagenic ruthenium(II)-based compounds with antitumoral activity.

de Camargo MS, da Silva MM, Correa RS, Vieira SD, Castelli S, D'Anessa I, De Grandis R, Varanda E, Deflon VM, Desideri A, Batista AA. de Camargo MS, et al. Among authors: desideri a. Metallomics. 2016 Feb;8(2):179-92. doi: 10.1039/c5mt00227c. Metallomics. 2016. PMID: 26758075

2

Effect on DNA relaxation of the single Thr718Ala mutation in human topoisomerase I: a functional and molecular dynamics study.

Chillemi G, Fiorani P, Castelli S, Bruselles A, Benedetti P, Desideri A. Chillemi G, et al. Among authors: desideri a. Nucleic Acids Res. 2005 Jun 8;33(10):3339-50. doi: 10.1093/nar/gki642. Print 2005. Nucleic Acids Res. 2005. PMID: 15944452 Free PMC article.

3

New hints on the Ph-driven tautomeric equilibria of the topotecan anticancer drug in aqueous solutions from an integrated spectroscopic and quantum-mechanical approach.

Sanna N, Chillemi G, Grandi A, Castelli S, Desideri A, Barone V. Sanna N, et al. Among authors: desideri a. J Am Chem Soc. 2005 Nov 9;127(44):15429-36. doi: 10.1021/ja052637u. J Am Chem Soc. 2005. PMID: 16262406

4

The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant.

Fiorani P, Chillemi G, Losasso C, Castelli S, Desideri A. Fiorani P, et al. Among authors: desideri a. Nucleic Acids Res. 2006;34(18):5093-100. doi: 10.1093/nar/gkl670. Epub 2006 Sep 20. Nucleic Acids Res. 2006. PMID: 16990249 Free PMC article.

5

Role of flexibility and long range communication on the function of human topoisomerase I.

Chillemi G, Fiorani P, Bruselles A, Castelli S, Campagna A, Sarra O, Tesauro C, Fiorentini M, Vassallo O, D'Annessa I, Santoleri S, Desideri A. Chillemi G, et al. Among authors: desideri a. Ital J Biochem. 2007 Jun;56(2):110-4. Ital J Biochem. 2007. PMID: 17722651 Review.

6

UV-vis spectra of the anticancer camptothecin family drugs in aqueous solution: specific spectroscopic signatures unraveled by a combined computational and experimental study.

Sanna N, Chillemi G, Gontrani L, Grandi A, Mancini G, Castelli S, Zagotto G, Zazza C, Barone V, Desideri A. Sanna N, et al. Among authors: desideri a. J Phys Chem B. 2009 Apr 23;113(16):5369-75. doi: 10.1021/jp809801y. J Phys Chem B. 2009. PMID: 19334673

7

Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin.

Castelli S, Campagna A, Vassallo O, Tesauro C, Fiorani P, Tagliatesta P, Oteri F, Falconi M, Majumder HK, Desideri A. Castelli S, et al. Among authors: desideri a. Arch Biochem Biophys. 2009 Jun 15;486(2):103-10. doi: 10.1016/j.abb.2009.04.007. Epub 2009 May 4. Arch Biochem Biophys. 2009. PMID: 19397888

8

Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis.

Bruzzese F, Rocco M, Castelli S, Di Gennaro E, Desideri A, Budillon A. Bruzzese F, et al. Among authors: desideri a. Mol Cancer Ther. 2009 Nov;8(11):3075-87. doi: 10.1158/1535-7163.MCT-09-0254. Epub 2009 Nov 3. Mol Cancer Ther. 2009. PMID: 19887547

9

Evidences of a natively unfolded state for the human topoisomerase IB N-terminal domain.

Vassallo O, Castelli S, D'Annessa I, della Rocca BM, Stella L, Knudsen BR, Desideri A. Vassallo O, et al. Among authors: desideri a. Amino Acids. 2011 Oct;41(4):945-53. doi: 10.1007/s00726-010-0794-x. Epub 2010 Nov 3. Amino Acids. 2011. PMID: 21046176

10

Inhibition of human DNA topoisomerase IB by a cyclometalated gold III compound: analysis on the different steps of the enzyme catalytic cycle.

Castelli S, Vassallo O, Katkar P, Che CM, Sun RW, Desideri A. Castelli S, et al. Among authors: desideri a. Arch Biochem Biophys. 2011 Dec 15;516(2):108-12. doi: 10.1016/j.abb.2011.10.008. Epub 2011 Oct 19. Arch Biochem Biophys. 2011. PMID: 22033340

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