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Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia.
Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. Wiesner P, et al. Among authors: gonen a. Circ Res. 2010 Jul 9;107(1):56-65. doi: 10.1161/CIRCRESAHA.110.218420. Epub 2010 May 20. Circ Res. 2010. PMID: 20489162 Free PMC article.
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity.
Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. Miller YI, et al. Among authors: gonen a. Circ Res. 2011 Jan 21;108(2):235-48. doi: 10.1161/CIRCRESAHA.110.223875. Circ Res. 2011. PMID: 21252151 Free PMC article. Review.
Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity.
Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Hilgendorf I, et al. Among authors: gonen a. Circulation. 2014 Apr 22;129(16):1677-87. doi: 10.1161/CIRCULATIONAHA.113.006381. Epub 2014 Jan 31. Circulation. 2014. PMID: 24488984 Free PMC article.
Interleukin-3/granulocyte macrophage colony-stimulating factor receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic ApoE deficiency.
Wang M, Subramanian M, Abramowicz S, Murphy AJ, Gonen A, Witztum J, Welch C, Tabas I, Westerterp M, Tall AR. Wang M, et al. Among authors: gonen a. Arterioscler Thromb Vasc Biol. 2014 May;34(5):976-84. doi: 10.1161/ATVBAHA.113.303097. Epub 2014 Mar 20. Arterioscler Thromb Vasc Biol. 2014. PMID: 24651678 Free PMC article.
Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine.
Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum JL, Hartvigsen K. Gonen A, et al. J Lipid Res. 2014 Oct;55(10):2137-55. doi: 10.1194/jlr.M053256. Epub 2014 Aug 20. J Lipid Res. 2014. PMID: 25143462 Free PMC article.
ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis.
Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum JL, Tarling EJ. Baldan A, et al. Among authors: gonen a. J Immunol. 2014 Dec 1;193(11):5637-48. doi: 10.4049/jimmunol.1400606. Epub 2014 Oct 22. J Immunol. 2014. PMID: 25339664 Free PMC article.
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